Evidence map›Paper›PMID 41959450›Full record

ArticlebioRxiv : the preprint server for biology2026

Generative machine learning unlocks the first proteome-wide image of human cells.

Huangqingbo Sun, Konstantin Kahnert, Jan N Hansen, William Leineweber, Mingyang Li, Wanyue Feng, Frederic Ballllosera, Ulrika Axelsson, Wei Ouyang, Emma Lundberg

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Huangqingbo SunDepartment of Bioengineering, Stanford University.ORCID 0000-0002-8206-511X
Konstantin KahnertDepartment of Bioengineering, Stanford University.ORCID 0000-0002-8454-4894
Jan N HansenDepartment of Bioengineering, Stanford University.ORCID 0000-0002-0489-7535
William LeineweberDepartment of Bioengineering, Stanford University.ORCID 0000-0003-3069-398X
Mingyang LiDepartment of Bioengineering, Stanford University.
Wanyue FengRay and Stephanie Lane Computational Biology Department, Carnegie Mellon University.
Frederic BalllloseraDepartment of Bioengineering, Stanford University.
Ulrika AxelssonScience for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology.ORCID 0000-0002-0273-9306
Wei OuyangScience for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology.
Emma LundbergDepartment of Bioengineering, Stanford University.ORCID 0000-0001-7034-0850

Funding

Bridge2AI: Cell Maps for AI (CM4AI) Data Generation ProjectOT2OD032742 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jean-Christophe Bélisle-Pipon, TIMOTHY W CLARK · 2022 to 2026
$21.5M
The Cancer Cell Map Initiative v2.0U54CA274502 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Trey Ideker · 2022 to 2026
$14.2M
NCI NIH HHS U54 CA274502NIH HHS OT2 OD032742
6 · The paper itself

Abstract

The spatial organization of proteins within cells governs virtually all cellular functions. Yet, current imaging technologies can simultaneously visualize only tens of proteins, orders of magnitude below the thousands that populate a single human cell. Here, we present

Indexed as

Bioimage InformaticsGenerative ModelingHuman Protein AtlasMachine LearningMicroscopySpatial ProteomicsSystems ProteomicsVirtual Cell ModelingVirtual Staining

Identifiers

PMID41959450
PMCPMC13060211

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.