Evidence map›Paper›PMID 41959445›Full record

ArticlebioRxiv : the preprint server for biology2026

Domain-Specific Agonist Binding Affinities Explain Structural and Functional Regulation of TRPM2.

Tatiana Kupriianova, Tessa Schwarzer, Thorben Thalacker, Lucas Defelipe, Stefanie Etzold, Frederike Kulow, Vanessa Pahl, Shivansh Goyal, Vanna Nguyen, Michael Zimmermann and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tatiana KupriianovaEuropean Molecular Biology Laboratory, Hamburg, Germany.
Tessa SchwarzerThe Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Thorben ThalackerEuropean Molecular Biology Laboratory, Hamburg, Germany.
Lucas DefelipeEuropean Molecular Biology Laboratory, Hamburg, Germany.
Stefanie EtzoldThe Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Frederike KulowThe Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Vanessa PahlEuropean Molecular Biology Laboratory, Heidelberg, Germany.
Shivansh GoyalDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.ORCID 0000-0003-3735-2475
Vanna NguyenDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.
Michael ZimmermannEuropean Molecular Biology Laboratory, Heidelberg, Germany.
Andreas H GuseThe Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Xiaolu A CambronneDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.ORCID 0000-0002-3547-448X
Henning TidowHamburg Advanced Research Centre for Bioorganic Chemistry (HARBOR) & Department of Chemistry, Institute for Biochemistry and Molecular Biology, University of Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany.
Ralf FliegertThe Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Maria Garcia AlaiEuropean Molecular Biology Laboratory, Hamburg, Germany.ORCID 0000-0002-5200-7816

Funding

Mitochondrial NAD+ in Acute Myeloid LeukemiasR01CA272490 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI Xiaolu Ang Cambronne · 2023 to 2026
$2.1M
Localized Real-time Sensors for Metabolic SignalingR35GM152218 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Xiaolu Ang Cambronne · 2024 to 2026
$1.1M
NCI NIH HHS R01 CA272490NIGMS NIH HHS R35 GM152218
6 · The paper itself

Abstract

TRPM2 is a Ca

Identifiers

PMID41959445
PMCPMC13060097

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.