Evidence map›Paper›PMID 41959435›Full record

ArticlebioRxiv : the preprint server for biology2026

ATF4-dependent upregulation of Bruno 1 remodels P-bodies to selectively protect mRNAs during ER stress throughout

Samantha N Milano, Livia V Bayer, Julie J Ko, Gwendolyn S Posner, Albina H Granovsky, Diana P Bratu

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Samantha N MilanoDepartment of Biological Sciences, Hunter College, City University of New York, NY, 10065 USA.ORCID 0009-0003-2516-5709
Livia V BayerDepartment of Biological Sciences, Hunter College, City University of New York, NY, 10065 USA.ORCID 0000-0003-0315-9300
Julie J KoDepartment of Biological Sciences, Hunter College, City University of New York, NY, 10065 USA.
Gwendolyn S PosnerDepartment of Biological Sciences, Hunter College, City University of New York, NY, 10065 USA.
Albina H GranovskyDepartment of Biological Sciences, Hunter College, City University of New York, NY, 10065 USA.
Diana P BratuDepartment of Biological Sciences, Hunter College, City University of New York, NY, 10065 USA.ORCID 0000-0002-8273-5961

Funding

Drosophila Transgenic RNAi Resource ProjectR01GM084947 · NIGMS · HARVARD MEDICAL SCHOOL · PI PERRIMON, NORBERT · 2008 to 2019
$9.8M
Characterizing P-bodies assembly and coordination of mRNA fate during Drosophila melanogaster oogenesisSC1GM135132 · NIGMS · HUNTER COLLEGE · PI BRATU, DIANA P. · 2020 to 2023
$1.6M
NIGMS NIH HHS R01 GM084947NIGMS NIH HHS SC1 GM135132
6 · The paper itself

Abstract

P-bodies are cytoplasmic membraneless organelles involved in mRNA storage, yet their role in cellular stress responses remains poorly understood. Here, we demonstrate that P-bodies are rapidly and selectively remodeled during the early response to endoplasmic reticulum (ER) stress in

Identifiers

PMID41959435
PMCPMC13060107

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.