In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
28 authors.
Ivana PačarUC Santa Cruz Genomics Institute and Biomolecular Engineering Department, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA.
Matteo Tommaso UngaroLaboratory of Genome Evolution, Department of Biology and Biotechnologies "Charles Darwin", University of Rome "La Sapienza", 00185 Rome, Italy.ORCID 0000-0002-1107-3307 Ying ChenThe Vertebrate Genome Laboratory, The Rockefeller University, 1230 York Ave, NY 10065, USA.ORCID 0000-0002-2237-6426 Hamza DallaliLaboratory of Genome Evolution, Department of Biology and Biotechnologies "Charles Darwin", University of Rome "La Sapienza", 00185 Rome, Italy.ORCID 0000-0002-3186-697X Jack A MedicoThe Vertebrate Genome Laboratory, The Rockefeller University, 1230 York Ave, NY 10065, USA.ORCID 0000-0003-1855-0855 Prajna HebbarUC Santa Cruz Genomics Institute and Biomolecular Engineering Department, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA.ORCID 0009-0008-9817-5330 Mark DiekhansUC Santa Cruz Genomics Institute and Biomolecular Engineering Department, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA.ORCID 0000-0002-0430-0989 Elena Di TommasoLaboratory of Genome Evolution, Department of Biology and Biotechnologies "Charles Darwin", University of Rome "La Sapienza", 00185 Rome, Italy.ORCID 0000-0001-6270-6189 Margarita GeletaBerkeley AI Research Laboratory, Department of Electrical Engineering and Computer Science, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0001-5823-9776 Patricia P ChanUC Santa Cruz Genomics Institute and Biomolecular Engineering Department, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA.ORCID 0000-0003-0810-1642 Todd M LoweUC Santa Cruz Genomics Institute and Biomolecular Engineering Department, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA.ORCID 0000-0003-3253-6021 Jennifer BalaccoThe Vertebrate Genome Laboratory, The Rockefeller University, 1230 York Ave, NY 10065, USA.
Nivesh JainThe Vertebrate Genome Laboratory, The Rockefeller University, 1230 York Ave, NY 10065, USA.
Francine AckermanThe Vertebrate Genome Laboratory, The Rockefeller University, 1230 York Ave, NY 10065, USA.ORCID 0009-0009-5957-829X Michela MochiDepartment of Molecular Medicine, University of Rome "La Sapienza", 00185 Rome, Italy.
Alexander G IoannidisUC Santa Cruz Genomics Institute and Biomolecular Engineering Department, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA.
Kasandra DiazThe New York Stem Cell Foundation, 619 W 54th St., NY, 10019 USA.
Kavitha Krishna SudhakarGarvan Institute of Medical Research, Darlinghurst 2010 Sydney, Australia.
Miten JainDepartment of Bioengineering, Department of Physics, Khoury College of Computer Sciences, Northeastern University, Boston, MA 02115, USA.
Alessandro RosaDepartment of Molecular Medicine, University of Rome "La Sapienza", 00185 Rome, Italy.ORCID 0000-0001-9999-7223 Erich D JarvisThe Vertebrate Genome Laboratory, The Rockefeller University, 1230 York Ave, NY 10065, USA.ORCID 0000-0001-8931-5049 Giulio FormentiThe Vertebrate Genome Laboratory, The Rockefeller University, 1230 York Ave, NY 10065, USA.ORCID 0000-0002-7554-5991 Sofie R SalamaUC Santa Cruz Genomics Institute and Biomolecular Engineering Department, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA.ORCID 0000-0001-6999-7193 Simona GiuntaLaboratory of Genome Evolution, Department of Biology and Biotechnologies "Charles Darwin", University of Rome "La Sapienza", 00185 Rome, Italy.ORCID 0000-0002-6666-9271 Funding
Dissecting the role of NOTCH2NL genes in human brain development and neurological disorders associated with chromosome 1q21.1 distal duplications and deletions.R01MH120295 · NIMH · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI SALAMA, SOFIE REDA · 2020 to 2024
$3.7MNIMH NIH HHS R01 MH120295
6 · The paper itselfAbstract
Advances in DNA sequencing and assembly technologies are spurring a shift from haploid reference genomes to sample-specific diploid assemblies. Here, we generated the first telomere-to-telomere (T2T) diploid reference for the widely used human embryonic stem cell (hESC) line, H9 (WAe009-A). This haplotype-resolved assembly is highly accurate with comprehensive annotation of genes, segmental duplications, methylation, and chromatin conformation. Pangenomic and phased-locus inference point to H9's mixed ancestry with a predominant European component. H9-specific genomic features include near-perfect telomeres ~1.65-fold longer than other T2T assemblies, consistent with telomerase activity during pluripotency; chromosome 17 inversions that can predispose offspring to neurological syndromes; and expansions of ncRNA clusters, with overall genomic stability maintained despite extensive culturing. Mapping multi-omic datasets to the genome, we demonstrate the power of this resource for allele-specific, high-precision transcriptomic, genetic, and epigenetic analyses, with far-reaching implications for human development and disease.
Indexed as
ancestry inferenceembryonic stem cellsgenome assemblyhaplotype resolutionpangenomicspluripotencytelomere-to-telomere
Identifiers
PMID41959420
PMCPMC13060304
What OpenQuestion holds
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