Evidence map›Paper›PMID 41959413›Full record

ArticlebioRxiv : the preprint server for biology2026

IL-22 promotes genesis of small intestinal secretory cells that protect against cholera in mice.

Masataka Suzuki, Yuko Hasegawa, Hailong Zhang, Zhu Liang, Guodong Tie, Ramesh A Shivdasani, Matthew K Waldor

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Masataka SuzukiDepartment of Microbiology, Harvard Medical School, Division of Infectious Diseases, Brigham & Women's Hospital, Howard Hughes Medical Institute, Boston, MA 02115.ORCID 0000-0001-5352-8595
Yuko HasegawaDepartment of Microbiology, Harvard Medical School, Division of Infectious Diseases, Brigham & Women's Hospital, Howard Hughes Medical Institute, Boston, MA 02115.ORCID 0000-0001-6890-3933
Hailong ZhangDepartment of Microbiology, Harvard Medical School, Division of Infectious Diseases, Brigham & Women's Hospital, Howard Hughes Medical Institute, Boston, MA 02115.
Zhu LiangDepartment of Microbiology, Harvard Medical School, Division of Infectious Diseases, Brigham & Women's Hospital, Howard Hughes Medical Institute, Boston, MA 02115.
Guodong TieDepartment of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Ramesh A ShivdasaniDepartment of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA.ORCID 0000-0002-2828-1727
Matthew K WaldorDepartment of Microbiology, Harvard Medical School, Division of Infectious Diseases, Brigham & Women's Hospital, Howard Hughes Medical Institute, Boston, MA 02115.ORCID 0000-0003-1843-7000

Funding

Vibrio cholerae intestinal colonization and vaccine developmentR01AI042347 · NIAID · TUFTS UNIVERSITY BOSTON · PI WALDOR, MATTHEW K · 1998 to 2025
$7.3M
Transcriptional control and enhancer recruitment in mouse and human intestinal secretory differentiationR01DK082889 · NIDDK · DANA-FARBER CANCER INST · PI Ramesh A Shivdasani · 2010 to 2026
$5.2M
NIAID NIH HHS R01 AI042347NIDDK NIH HHS R01 DK082889
6 · The paper itself

Abstract

The diarrheal disease cholera remains a global threat, but there is limited knowledge of the innate immune defenses in the small intestine that protect against the causative agent,

Identifiers

PMID41959413
PMCPMC13060058

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.