Evidence map›Paper›PMID 41959412›Full record

ArticlebioRxiv : the preprint server for biology2026

Passive neuromodulation: an energy-driven mechanism for closed-loop suppression of epileptic seizures.

Gagan Acharya, Andrew Huang, Vijayalakshmi Santhakumar, Erfan Nozari

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gagan AcharyaDepartment of Electrical and Computer Engineering, University of California, Riverside, CA, USA.
Andrew HuangDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA.
Vijayalakshmi SanthakumarDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA.ORCID 0000-0001-6278-4187
Erfan NozariDepartment of Electrical and Computer Engineering, University of California, Riverside, CA, USA.

Funding

Contribution of Innate Immune Receptors to Neurological Dysfunction After Traumatic Brain Injury: Mechanisms and Therapeutic ImplicationsR01NS097750 · NINDS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI SANTHAKUMAR, VIJAYALAKSHMI · 2016 to 2025
$4.0M
Inhibitory Network Plasticity in Neurological DiseaseR37NS069861 · NINDS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Vijayalakshmi Santhakumar · 2024 to 2026
$2.1M
Cellular Mediators of Dentate Pattern Separation in EpilepsyF31NS131052 · NINDS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI HUANG, ANDREW · 2023 to 2024
$85k
NINDS NIH HHS F31 NS131052NINDS NIH HHS R01 NS097750NINDS NIH HHS R37 NS069861
6 · The paper itself

Abstract

For decades, electrical neuromodulation has been used as a therapeutic mechanism to disrupt and desynchronize pathological neural activity in various neurological disorders. Despite notable progress, however, patient outcomes remain highly variable, particularly in medically intractable epilepsy where surgery still provides the greatest chance of seizure freedom. Here we propose

Identifiers

PMID41959412
PMCPMC13060320

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.