ArticlebioRxiv : the preprint server for biology2026
Synthetic budding morphogenesis by optogenetic receptor tyrosine kinase signaling.
Louis S Prahl, Ronald Canlla, Aria Zheyuan Huang, Daniel S Alber, Sandra L Shefter, Sachin N Davis, Samuel H Grindel, Zikang Dennis Huang, Thomas R Mumford, William Benman and 3 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Ronald CanllaDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA USA.
Aria Zheyuan HuangDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA USA.
Daniel S AlberDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA USA.
Sandra L ShefterDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA USA.
Sachin N DavisDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA USA.
Samuel H GrindelDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA USA.
Zikang Dennis HuangDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA USA.
Thomas R MumfordDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA USA.
William BenmanDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA USA.
Lukasz J BugajDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA USA.
Kyle W McCrackenCenter for Stem Cell and Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Cincinnati, OH USA.ORCID 0000-0001-7650-5513 Funding
Pediatric Center--Gene Expression /Developmental ScienceK12HD028827 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI Tina Lee Cheng · 2002 to 2026
$9.6MA developmental engineering toolbox for large-scale tissue engineeringR35GM133380 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Alex Hughes · 2019 to 2026
$3.3MHarnessing protein clustering to understand, identify, and manipulate cellular systemsR35GM138211 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Lukasz Bugaj · 2020 to 2026
$3.3MTraining CoreTL1DK143326 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Wei Tong · 2024 to 2026
$2.5MEngineering induction and assembly of human kidney tissueR01DK132296 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI HUGHES, ALEX · 2022 to 2025
$1.8MThe Philadelphia Program for Mentored Research Training in Kidney, Urologic, and Hematologic Diseases (PERFORM-KUH U2C/Tl1)U2CDK136784 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Michelle Denburg · 2024 to 2026
$1.8MAcquisition of a Cell Sorter for Systems Biology and Cellular EngineeringS10OD026986 · OD · UNIVERSITY OF PENNSYLVANIA · PI BUGAJ, LUKASZ · 2020 to 2020
$439kSynthetic approaches to study cell polarity related kidney defectsF32DK126385 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI PRAHL, LOUIS SKJEI · 2020 to 2023
$209kNICHD NIH HHS K12 HD028827NIDDK NIH HHS F32 DK126385NIDDK NIH HHS R01 DK132296NIDDK NIH HHS TL1 DK143326NIDDK NIH HHS U2C DK136784NIGMS NIH HHS R35 GM133380NIGMS NIH HHS R35 GM138211NIH HHS S10 OD026986
6 · The paper itselfAbstract
The mammalian kidney relies on a branched network of collecting ducts for fluid transport and homeostasis. Replicating this network
Indexed as
branching morphogenesisdevelopmentEpithelial cellskidneyoptogeneticsorganogenesisorganoidreceptor tyrosine kinase signalingsynthetic morphogenesis
Identifiers
PMID41959406
PMCPMC13060360
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