Evidence map›Paper›PMID 41959404›Full record

ArticlebioRxiv : the preprint server for biology2026

Syngap1 Synchronizes Relative Neuronal Maturation Across Cortical Areas to Organize Distributed Functional Networks.

Randall M Golovin, Bianca Garcia-Gonzalez, Sheldon D Michaelson, Massimiliano Aceti, Seth Butz, Camilo Rojas, Courtney A Miller, Thomas Vaissiere, Gavin Rumbaugh

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Randall M GolovinDepartments of Neuroscience and Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.ORCID 0000-0003-1510-6126
Bianca Garcia-GonzalezThe Skaggs Graduate School of Chemical and Biological Sciences at Scripps Research, Jupiter, FL, USA.ORCID 0009-0007-6436-4929
Sheldon D MichaelsonDepartments of Neuroscience and Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.ORCID 0009-0001-2764-7264
Massimiliano AcetiDepartments of Neuroscience and Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.ORCID 0000-0002-6632-1398
Seth ButzDepartments of Neuroscience and Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.
Camilo RojasDepartments of Neuroscience and Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.
Courtney A MillerDepartments of Neuroscience and Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.ORCID 0000-0001-8628-4902
Thomas VaissiereDepartments of Neuroscience and Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.ORCID 0000-0001-9510-7510
Gavin RumbaughDepartments of Neuroscience and Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.ORCID 0000-0001-6360-3894

Funding

Intersection of causal neurodevelopmental disorder risk genes, cortical circuit function, and cognitive processing required for behavioral adaptionsR01MH096847 · NIMH · UNIVERSITY OF FLORIDA · PI Courtney A Miller, GAVIN R RUMBAUGH · 2012 to 2026
$10.4M
Neurodevelopmental Disorder Risk Gene Regulation of Intrinsic Membrane Excitability: A Rheostat that Tunes Dendritic Morphogenesis to Regulate Circuit Assembly During DevelopmentR01MH131788 · NIMH · UNIVERSITY OF FLORIDA · PI GAVIN R RUMBAUGH · 2022 to 2026
$3.4M
Causal Interactions between genetic risk, precise cortical connectivity, and autism-associated behaviorsR01NS110307 · NINDS · UNIVERSITY OF FLORIDA · PI RUMBAUGH, GAVIN R · 2020 to 2024
$2.6M
Impact of autism genetic risk on cortical sensorimotor dynamicsF32MH130163 · NIMH · UNIVERSITY OF FLORIDA · PI GOLOVIN, RANDALL M. · 2023 to 2025
$232k
NIMH NIH HHS F32 MH130163NIMH NIH HHS R01 MH096847NIMH NIH HHS R01 MH131788NINDS NIH HHS R01 NS110307
6 · The paper itself

Abstract

Neurodevelopmental disorders are increasingly viewed as disorders of distributed brain networks, yet how developmental perturbations generate co-occurring hypo- and hyper-functional network states remains unclear. We show that

Identifiers

PMID41959404
PMCPMC13060220

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.