Evidence map›Paper›PMID 41959390›Full record

ArticlebioRxiv : the preprint server for biology2026

Sustained interferon exposure creates a hyper-metastatic subset of melanoma cells.

Mark H Mannino, Tao Wei, Daniel Cassidy, Benjamin Knight, Devon L Moose, Adrienne Shannon, Elena Piskounova, Zhiyu Zhao, Sean J Morrison

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mark H ManninoChildren's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Tao WeiChildren's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Daniel CassidyChildren's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Benjamin KnightChildren's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Devon L MooseChildren's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Adrienne ShannonDepartment of Surgery, Surgical Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Elena PiskounovaDepartment of Pathology, Beth Israel Deaconess Medical Center. Boston, MA, 02215.
Zhiyu ZhaoChildren's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Sean J MorrisonChildren's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

Funding

UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Kathryn Ann O'Donnell · 2010 to 2026
$53.7M
Technical Development Unit 2: Intelligent Hyperspectral Imaging of Subcellular Molecular States at the Whole Organ LevelU54CA268072 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI SEAN J MORRISON · 2021 to 2026
$9.1M
The Metabolic Regulation of Melanoma MetastasisU01CA228608 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MORRISON, SEAN J · 2019 to 2023
$2.9M
NCI NIH HHS P30 CA142543NCI NIH HHS U01 CA228608NCI NIH HHS U54 CA268072
6 · The paper itself

Abstract

We generated interferon signaling reporters in human and mouse melanoma cells and observed heterogeneity in interferon responses among cells in the same tumors. This was marked by inflamed regions within primary tumors that contained increased numbers of interferon-expressing macrophages/monocytes and elevated type I interferon signaling in melanoma cells. Melanoma cells that expressed GFP-Interferon stimulated gene 15 (ISG15) or GFP-Interferon-induced protein with tetraticopeptide repeats 3 (IFIT3) fusion reporters exhibited a profoundly increased ability to form metastatic tumors as compared to GFP-ISG15

Identifiers

PMID41959390
PMCPMC13060131

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.