Evidence map›Paper›PMID 41959357›Full record

ArticlebioRxiv : the preprint server for biology2026

LSD1 ablation promotes mammary tumor metastasis by attenuating NK cell-mediated anti-tumor immunity.

Dongxi Xiang, Sen Han, Aina He, Guyu Qin, Roderick T Bronson, Zhe Li

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dongxi XiangDivision of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Sen HanDivision of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Aina HeDivision of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Guyu QinDivision of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Roderick T BronsonRodent Histopathology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Zhe LiDivision of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.ORCID 0000-0002-3434-0885

Funding

Mechanism of LSD1 in breast cancer metastasis suppressionR01CA248306 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI LI, ZHE · 2021 to 2025
$1.9M
Interplay of mammary luminal cells and environmental factors in establishing p53-deficient premalignant fieldR01CA222560 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI LI, ZHE · 2018 to 2022
$1.9M
NCI NIH HHS R01 CA222560NCI NIH HHS R01 CA248306
6 · The paper itself

Abstract

Epigenetic deregulation can alter the expression of cancer-related genes in tumor cells and may promote metastasis by influencing interactions between tumor cells and their immune microenvironment. However, the underlying immune mechanisms remain poorly understood. LSD1 (KDM1A) is a histone demethylase that has been proposed to function as a tumor and metastasis suppressor in breast cancer. Here, using the

Indexed as

Epigenetic regulatorimmune microenvironmentLSD1 (KDM1A)luminal breast cancer metastasisNK cells

Identifiers

PMID41959357
PMCPMC13061030

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.