Evidence map›Paper›PMID 41959350›Full record

ArticlebioRxiv : the preprint server for biology2026

Bile acid dependent attenuation of toxin mediated disease is independent of colonization resistance against

Samantha C Kisthardt, C E Perkins, Abigail S Gancz, Noah S Lyons, Stephanie A Thomas, Emily C Vincent, Guozhi Zhang, John Tam, Roman Melnyk, Elizabeth C Rose and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Samantha C KisthardtDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University Raleigh, NC 27607.
C E PerkinsDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University Raleigh, NC 27607.
Abigail S GanczDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University Raleigh, NC 27607.
Noah S LyonsDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University Raleigh, NC 27607.
Stephanie A ThomasDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University Raleigh, NC 27607.
Emily C VincentDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Guozhi ZhangDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
John TamMolecular Medicine Program, The Hospital for Sick Children Research Institute, 686 Bay Street Toronto, ON, Canada, M5G 0A4.
Roman MelnykMolecular Medicine Program, The Hospital for Sick Children Research Institute, 686 Bay Street Toronto, ON, Canada, M5G 0A4.
Elizabeth C RoseDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University Raleigh, NC 27607.
Erin S BakerDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0001-5246-2213
Casey M TheriotDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University Raleigh, NC 27607.

Funding

PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1985 to 2026
$30.5M
Single cell, multi-parametric high throughput platform to classify endocrine disruptor potential of mixturesP42ES027704 · NIEHS · TEXAS A&M UNIVERSITY · PI Efstratios Pistikopoulos · 2017 to 2026
$21.2M
Understanding the role of lipids in structure and function of membrane proteinsRM1GM145416 · NIGMS · TEXAS A&M UNIVERSITY · PI Erin S Baker, Arthur D Laganowsky · 2022 to 2026
$7.4M
NC STATE MOLECULAR BIOTECHNOLOGY TRAINING PROGRAM (MBTP)T32GM133366 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Jason M. Haugh, Robert M Kelly · 2020 to 2026
$3.3M
Targeted bacterial restoration of colonization resistance against C. difficileR35GM119438 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI THERIOT, CASEY MICHELLE · 2016 to 2020
$1.6M
The interplay between nutrient availability and secondary bile acid metabolism in commensal Clostridia mediates colonization resistance against C. difficileR35GM149222 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Casey Michelle Theriot · 2023 to 2026
$1.5M
Increasing the Coverage, Sensitivity and Specificity of Rapid Lipidomic MeasurementsR01GM141277 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BAKER, ERIN S · 2022 to 2025
$1.2M
NIDDK NIH HHS P30 DK034987NIEHS NIH HHS P42 ES027704NIGMS NIH HHS R01 GM141277NIGMS NIH HHS R35 GM119438NIGMS NIH HHS R35 GM149222NIGMS NIH HHS RM1 GM145416NIGMS NIH HHS T32 GM133366
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

bile acidsbile salt hydrolasecholateClostridioides difficileClostridium hiranonisClostridium scindenscompetitiondeoxycholateinflammationtoxin

Identifiers

PMID41959350
PMCPMC13061041

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.