Evidence map›Paper›PMID 41959339›Full record

ArticlebioRxiv : the preprint server for biology2026

Pharmacologic DPP-4 inhibition promotes CD8

Oriana Y Teran Pumar, Elton L VanNoy, Abigail Haffey, Durga Prasad Gannamedi, Christine Isabelle Rafie, Dylan Scott Lykke Harwood, Julia R Benedetti, Christine Ann Pittman Ballard, Erika Ciervo, Pedro Henrique Assenza Tavares Coroa and 23 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Oriana Y Teran PumarDepartment of Molecular & Cellular Pharmacology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
Elton L VanNoyGeorge Washington University, School of Medicine and Health Sciences, USA.
Abigail HaffeyGeorge Washington University, School of Medicine and Health Sciences, USA.
Durga Prasad GannamediSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Christine Isabelle RafieDepartment of Microbiology & Immunology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
Dylan Scott Lykke HarwoodThe Bartholin Institute, Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Julia R BenedettiDepartment of Neurosurgery, Duke University School of Medicine, Durham, NC, USA.
Christine Ann Pittman BallardDepartment of Neurosurgery, Duke University School of Medicine, Durham, NC, USA.
Erika CiervoSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Pedro Henrique Assenza Tavares CoroaLeonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
Payal GroverDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA.
Brandon Emanuel LeónDepartment of Molecular & Cellular Pharmacology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
Jonathan MitchellDepartment of Molecular & Cellular Pharmacology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
Asmita PathakDepartment of Molecular & Cellular Pharmacology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
Bruno ColonDepartment of Molecular & Cellular Pharmacology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
Lyenne El GhorayebChildren's National Research Institute, USA.
Laura O'SullivanDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA.
Venu Venkatarame Gowda SaralammaSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Clara Lopez RuizLeonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
Natasha KhatwaniDepartment of Pathology and Laboratory Medicine, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
Surinder KumarSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Priyamvada RaiSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.ORCID 0000-0001-7822-7553
Jonathan SchatzSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Ashish ShahSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Zev A BinderDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA.
Michele CeccarelliSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Quinn T OstromDepartment of Neurosurgery, Duke University School of Medicine, Durham, NC, USA.
Bjarne Winther KristensenThe Bartholin Institute, Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Erietta StelekatiSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Dionysios C WatsonSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
David B LombardSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Dalia HaydarGeorge Washington University, School of Medicine and Health Sciences, USA.
Defne BayikDepartment of Molecular & Cellular Pharmacology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.ORCID 0000-0002-4740-8869

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DAVID A. MANKOFF · 1985 to 2026
$222.3M
Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI Lee Zou · 1985 to 2026
$174.8M
Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Una T O'Doherty · 1999 to 2026
$78.6M
Tumor Biology Research ProgramP30CA240139 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Lauren Ashley Whitmore · 2019 to 2026
$24.1M
SIRT5 inhibitors and degraders as novel treatments for Ewing sarcomaR01CA253986 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Benner Lombard, NOURI NEAMATI · 2022 to 2026
$2.1M
Development and validation of an autologous mouse model for the study of immune interactions with glioblastomaR37CA285434 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Zev Ari Binder · 2024 to 2026
$2.0M
Role of myeloid-derived suppressor cells in local and systemic immunosuppression in glioblastomaR00CA248611 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BAYIK WATSON, DEFNE · 2023 to 2025
$943k
Improving CAR T cell therapy for brain tumors using immune competent modelsR00CA256262 · NCI · CHILDREN'S RESEARCH INSTITUTE · PI HAYDAR, DALIA · 2023 to 2025
$713k
Mitochondrial transfer from astrocytes to glioblastoma cells drives tumor growthR00CA277242 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Dionysios C Watson · 2024 to 2026
$632k
Improving CAR T cell therapy for brain tumors using immune competent modelsK99CA256262 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI HAYDAR, DALIA · 2021 to 2022
$250k
NCI NIH HHS HHSN261201800009CNCI NIH HHS HHSN261201800009INCI NIH HHS HHSN261201800015CNCI NIH HHS HHSN261201800015INCI NIH HHS HHSN261201800032CNCI NIH HHS HHSN261201800032INCI NIH HHS K99 CA256262NCI NIH HHS P30 CA014236NCI NIH HHS P30 CA016520NCI NIH HHS P30 CA240139NCI NIH HHS R00 CA248611NCI NIH HHS R00 CA256262NCI NIH HHS R00 CA277242NCI NIH HHS R01 CA253986NCI NIH HHS R37 CA285434NIAID NIH HHS P30 AI045008
6 · The paper itself

Abstract

Metabolic dysfunction is a hallmark of CD8

Identifiers

PMID41959339
PMCPMC13060269

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.