In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Eric M CramerMedical Scientist Training Program, Oregon Health & Science University School of Medicine, Portland, OR, USA.ORCID 0000-0003-2085-3679 Randy HeilandDepartment of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA.ORCID 0000-0002-7440-2905 Heber Lima da RochaDepartment of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA.ORCID 0000-0002-5876-2644 Daniel R BergmanInstitute for Genome Sciences and Greenebaum Comprehensive Cancer Center, School of Medicine, University of Maryland, Baltimore, MD, USA.ORCID 0000-0002-2166-6616 Joe W GrayDepartment of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.ORCID 0000-0001-9225-6756 Elana J FertigInstitute for Genome Sciences and Greenebaum Comprehensive Cancer Center, School of Medicine, University of Maryland, Baltimore, MD, USA.ORCID 0000-0003-3204-342X Paul MacklinDepartment of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA.ORCID 0000-0002-9925-0151 Laura M HeiserDepartment of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.ORCID 0000-0003-3330-0950 Young Hwan ChangDepartment of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.ORCID 0000-0001-8764-1959 Funding
Medical Scientist Training Program of Oregon Health & Science UniversityT32GM141938 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI CHEN, YABING · 2021 to 2025
$4.6MSystematic Characterization and Targeting of Neomorphic Drivers in CancerU01CA281902 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Benjamin Deneen, Han Liang · 2023 to 2026
$3.5MInforming mechanistic rules of agent-based models with single-cell multi-omicsU24CA284156 · NCI · TRUSTEES OF INDIANA UNIVERSITY · PI Elana Fertig, Paul T Macklin · 2024 to 2026
$2.3MIntegrated Training in Quantitative and Experimental Cancer Systems BiologyT32CA254888 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Sudarshan Anand, LISA M COUSSENS · 2021 to 2026
$2.2MHigh Performance Computing and Machine Learning Infrastructure for Oregon Life SciencesS10OD034224 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLROTT, KYLE · 2023 to 2023
$2.0MNCI NIH HHS T32 CA254888NCI NIH HHS U01 CA281902NCI NIH HHS U24 CA284156NIGMS NIH HHS T32 GM141938NIH HHS S10 OD034224
6 · The paper itselfAbstract
Multiplexed tissue imaging (MTI) has revealed recurrent tumor microenvironment (TME) architectures with prognostic value, yet these measurements are inherently static, obscuring dynamic changes in the TME that govern therapeutic response. Here, we introduce a trajectory-centric framework that reconstructs continuous TME dynamics by integrating agent-based mathematical modeling and simulation with state space analysis. This approach yields a mechanistically constrained reference landscape built entirely from
Identifiers
PMID41959335
PMCPMC13060115
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