Evidence map›Paper›PMID 41959330›Full record

ArticlebioRxiv : the preprint server for biology2026

Mapping the mammalian dark metabolome by

Michael R MacArthur, Justine Raeber, Wenyun Lu, Hantao Qiang, Amelia V Schueppert, Lucas B Ayres, Ricardo A Cordova, Michael D Neinast, Edmundo Leiva, Vanha N Pham and 15 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Michael R MacArthurLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Justine RaeberLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Wenyun LuLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Hantao QiangLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Amelia V SchueppertLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Lucas B AyresLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Ricardo A CordovaLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Michael D NeinastLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Edmundo LeivaLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Vanha N PhamLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Jenna E AbuSalimLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Connor S R JankowskiLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Laith Z SamarahLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Asael RoichmanLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Christian G PeaceLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Daniil G IvanovLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Gianna L RenzoDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Anna M OschmannLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Julien F AyrolesDepartment of Integrative Biology, University of California Berkeley, Berkeley, CA, USA.
Sarah J MitchellLudwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ, USA.
Xi XingLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Kellen OlszewskiLudwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ, USA.
Hahn KimLudwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ, USA.
Joshua D RabinowitzLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Michael A SkinniderLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-2168-1621

Funding

TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Tracie Saunders · 1997 to 2026
$94.5M
VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI DOUGLAS J EPSTEIN · 1986 to 2026
$48.3M
Revealing cancer metabolism via mass spectrometry and isotope tracersR50CA211437 · NCI · PRINCETON UNIVERSITY · PI Wenyun Lu · 2016 to 2026
$1.3M
A machine-learning platform to illuminate the chemical dark matter in mass spectrometry-based metabolomicsDP5OD036960 · OD · PRINCETON UNIVERSITY · PI Michael Alexander Skinnider · 2024 to 2026
$1.2M
NCI NIH HHS P30 CA072720NCI NIH HHS R50 CA211437NIDDK NIH HHS P30 DK019525NIH HHS DP5 OD036960
6 · The paper itself

Abstract

Despite decades of biochemical study, a comprehensive map of the mammalian metabolome remains elusive. Mass spectrometry-based metabolomics detects thousands of small molecule-associated signals in mammalian tissues, but it is currently unclear how many of these reflect products of endogenous metabolism. Here, we leverage systematic

Identifiers

PMID41959330
PMCPMC13060188

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.