Evidence map›Paper›PMID 41959304›Full record

ArticlebioRxiv : the preprint server for biology2026

Developmental Correlates of Epigenetic and Polygenic Indices of Cognition and Educational Attainment from Birth to Young Adulthood.

D Fraemke, L Paulus, I Schuurmans, J-H Walter, D Czamara, A M Schowe, A deSteiguer, P T Tanksley, A Okbay, B Mönkediek and 14 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

D FraemkeMax Planck Research Group Biosocial - Biology, Social Disparities, and Development, Max Planck Institute for Human Development, Berlin, Germany.
L PaulusDepartment of Individual Differences & Psychodiagnostics, Saarland University, Saarbrücken, Germany.
I SchuurmansDepartment of Child and Adolescent Psychiatry and Psychology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands.
J-H WalterMax Planck Research Group Biosocial - Biology, Social Disparities, and Development, Max Planck Institute for Human Development, Berlin, Germany.
D CzamaraDepartment Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany.
A M SchoweDepartment Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany.
A deSteiguerDepartment of Psychology, University of Texas at Austin, Austin, TX, USA.
P T TanksleyALERRT Center, Texas State University, San Marcos, TX, USA.
A OkbaySchool of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
B MönkediekDepartment of Psychology, Bielefeld University, Bielefeld, Germany.
J InstinskeDepartment of Psychology, Bielefeld University, Bielefeld, Germany.
M M NöthenInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
C K L DißelkampInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
A J ForstnerInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
E B BinderDepartment Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany.
C KandlerDepartment of Psychology, Bielefeld University, Bielefeld, Germany.
F M SpinathDepartment of Individual Differences & Psychodiagnostics, Saarland University, Saarbrücken, Germany.
U LindenbergerCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.
M MalanchiniCentre for Brain and Behaviour, School of Biological and Behavioural Sciences, Queen Mary University of London, London, UK.
C A M CecilDepartment of Child and Adolescent Psychiatry and Psychology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands.
C MitchellSurvey Research Center and Population Studies Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
K P HardenDepartment of Psychology, University of Texas at Austin, Austin, TX, USA.
E M Tucker-DrobDepartment of Psychology, University of Texas at Austin, Austin, TX, USA.
L RaffingtonMax Planck Research Group Biosocial - Biology, Social Disparities, and Development, Max Planck Institute for Human Development, Berlin, Germany.

Funding

Scientific & Technical CoreP2CHD042849 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI MARK D. HAYWARD · 2017 to 2026
$5.2M
Environmental, Genetic, and Epigenetic Mechanisms for Hormonal ChangeR01HD092548 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI HARDEN, KATHRYN PAIGE · 2019 to 2023
$3.0M
Epigenetic Pathways of Socioeconomic Disparities in Physical and Cognitive Health Across the LifespanR01HD114724 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI Kathryn Paige Harden, Laurel Raffington · 2024 to 2026
$1.7M
Large-Scale Genomic Analysis of Aging-Related Cognitive Change Prior to Dementia OnsetR01AG073593 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI TUCKER-DROB, ELLIOT MAX · 2024 to 2025
$1.3M
NIA NIH HHS R01 AG073593NICHD NIH HHS P2C HD042849NICHD NIH HHS R01 HD092548NICHD NIH HHS R01 HD114724
6 · The paper itself

Abstract

Large-scale genomic studies have identified biomarkers of adult cognitive functioning and educational attainment, yet the developmental pathways connecting these biomarkers to adult outcomes remain unclear. Drawing on four cohorts, we examined the developmental correlates of an epigenetic index of adult cognitive function ('Epigenetic-

Indexed as

Cognitive DevelopmentDNA methylationEducationEpigeneticsGene-Environment InterplayPolygenic Indices

Identifiers

PMID41959304
PMCPMC13060311

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.