Evidence map›Paper›PMID 41959295›Full record

ArticlebioRxiv : the preprint server for biology2026

Patient-derived organoid xenografts reveal the multifaceted role of the lncRNA

Disha Aggarwal, Suzanne Russo, Kendall Anderson, Taylor Floyd, Raditya Utama, James A Rouse, Payal Naik, Sara Pawlak, Shruti V Iyer, Melissa Kramer and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Disha AggarwalCold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
Suzanne RussoCold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
Kendall AndersonEnvisagenics, Long Island City, New York, USA.
Taylor FloydEnvisagenics, Long Island City, New York, USA.
Raditya UtamaCold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
James A RouseCold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
Payal NaikCold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
Sara PawlakCold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
Shruti V IyerCold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
Melissa KramerCold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
Shuchismita SatpathyCold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
John E WilkinsonCold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
Qing GaoCold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
Sonam BhatiaCold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
Gayatri ArunEnvisagenics, Long Island City, New York, USA.
Martin AkermanEnvisagenics, Long Island City, New York, USA.
W Richard McCombieCold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
Alexey RevenkoIonis Pharmaceuticals, Carlsbad, California, USA.
Karen KostroffDivision of Surgical Oncology, Northwell Health, New Hyde Park, New York, USA.
David L SpectorCold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.

Funding

Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI David A Tuveson · 1987 to 2026
$118.9M
VIRAL TRANSACTIVATIONP01CA013106 · NCI · COLD SPRING HARBOR LABORATORY · PI William Richard McCombie · 1985 to 2026
$116.8M
Acquisition of a Zeiss LSM 980 Confocal Microscope with Airyscan CapabilityS10OD034372 · OD · COLD SPRING HARBOR LABORATORY · PI SPECTOR, DAVID L · 2023 to 2023
$600k
Graphical Processing Units and a Large-Memory Compute Node for Applications in Genomics, Neuroscience, and Structural BiologyS10OD028632 · OD · COLD SPRING HARBOR LABORATORY · PI SIEPEL, ADAM CHARLES · 2020 to 2020
$437k
NCI NIH HHS P01 CA013106NCI NIH HHS P30 CA045508NIH HHS S10 OD028632NIH HHS S10 OD034372
6 · The paper itself

Abstract

Background: Long non-coding RNAs (lncRNAs) have emerged as key regulators of tumor biology, however, thus far none have translated to cancer therapies. The lncRNA Methods: We investigated the therapeutic potential of a Results: Across PDO-X models, Conclusions: Our data define

Indexed as

breast cancerlncRNAMALAT1metastasisOrganoidspatient-derived modelssplicingTNBC

Identifiers

PMID41959295
PMCPMC13060066

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.