Evidence map›Paper›PMID 41959290›Full record

ArticlebioRxiv : the preprint server for biology2026

Structural Basis of a Novel Heme Binding Bacterial One-Component Switch.

James J Siclari, Malvin Forson, Cullen Roeder, Eta A Isiorho, Denize C Favaro, Rinat R Abzalimov, Stephen S Gisselbrecht, Alec H Follmer, Martha L Bulyk, Kevin H Gardner

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

James J SiclariStructural Biology Initiative, CUNY Advanced Science Research Center, New York, NY 10031.ORCID 0000-0001-5275-4515
Malvin ForsonStructural Biology Initiative, CUNY Advanced Science Research Center, New York, NY 10031.ORCID 0000-0001-8810-4039
Cullen RoederStructural Biology Initiative, CUNY Advanced Science Research Center, New York, NY 10031.ORCID 0009-0007-8791-2668
Eta A IsiorhoStructural Biology Initiative, CUNY Advanced Science Research Center, New York, NY 10031.ORCID 0000-0002-6242-9297
Denize C FavaroStructural Biology Initiative, CUNY Advanced Science Research Center, New York, NY 10031.ORCID 0000-0001-5563-2548
Rinat R AbzalimovStructural Biology Initiative, CUNY Advanced Science Research Center, New York, NY 10031.ORCID 0000-0003-2110-1532
Stephen S GisselbrechtDivision of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.ORCID 0000-0001-8723-902X
Alec H FollmerDepartment of Chemistry, University of California -Davis, Davis, CA 95616, USA.ORCID 0000-0002-6244-6804
Martha L BulykDivision of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-3456-4555
Kevin H GardnerStructural Biology Initiative, CUNY Advanced Science Research Center, New York, NY 10031.ORCID 0000-0002-8671-2556

Funding

Summer Undergraduate Research Support - Ms. Anastasiia FisiukR01GM106239 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI GARDNER, KEVIN H · 2013 to 2024
$4.5M
PAS proteins: Study and application of signaling mechanismsR35GM156296 · NIGMS · ADVANCED SCIENCE RESEARCH CENTER · PI Kevin H Gardner · 2025 to 2026
$1.1M
NIGMS NIH HHS R01 GM106239NIGMS NIH HHS R35 GM156296
6 · The paper itself

Abstract

One-component systems (OCSs) integrate sensory and effector functions within a single protein, enabling rapid gene expression changes in response to environmental cues. Here, we characterized a novel putative OCS protein, FG214, from

Indexed as

Bacterial SignalingHeme Binding ProteinsOne-Component SystemsPer-ARNT-Sim domains

Identifiers

PMID41959290
PMCPMC13060918

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.