Evidence map›Paper›PMID 41959286›Full record

ArticlebioRxiv : the preprint server for biology2026

A human subcortical connectome at 400 μm resolution.

Chiara Maffei, Ting Gong, Clemens Neudorfer, Dongsuk Sung, Dey Mihir, Kabilar Gunala, Satrajit Ghosh, Jean C Augustinack, Susie Y Huang, Robert M Richardson and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chiara MaffeiAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.ORCID 0000-0002-3837-0635
Ting GongAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Clemens NeudorferDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Dongsuk SungAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Dey MihirUniversity of Cincinnati - College of Engineering and Applied Science, OH, USA.
Kabilar GunalaMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Satrajit GhoshMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.ORCID 0000-0002-5312-6729
Jean C AugustinackAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Susie Y HuangAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.ORCID 0000-0003-2950-7254
Robert M RichardsonDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2620-7387
Suzanne N HaberDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Massachusetts.
Anastasia YendikiAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.

Funding

BRAIN CONNECTS: The center for Large-scale Imaging of Neural Circuits (LINC)UM1NS132358 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Suzanne N Haber, Elizabeth M. C. Hillman · 2023 to 2026
$17.5M
CONNECTOME 2.0: DEVELOPING THE NEXT GENERATION HUMAN MRI SCANNER FOR BRIDGING STUDIES OF THE MICRO-, MESO- AND MACRO-CONNECTOMEU01EB026996 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BASSER, PETER J., HUANG, SUSIE YI · 2018 to 2022
$14.2M
Bridging Diffusion MRI and Chemical Tracing for Validation and Inference of Fiber ArchitecturesR01NS119911 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI YENDIKI, ANASTASIA · 2021 to 2024
$2.6M
Mapping Human Neurocircuitry Across Scales with Diffusion MRI and Optical ImagingR01NS127353 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Anastasia Yendiki · 2024 to 2026
$1.9M
NIBIB NIH HHS U01 EB026996NINDS NIH HHS R01 NS119911NINDS NIH HHS R01 NS127353NINDS NIH HHS UM1 NS132358
6 · The paper itself

Abstract

The fiber pathways of the human subcortex are of particular importance in clinical neuroscience, as they are targeted by neuromodulation therapies, such as deep brain stimulation (DBS) and lesion approaches, in various motor and psychiatric disorders. However, the complexity, size, and position of these pathways make them challenging to image non-invasively with diffusion MRI (dMRI). As a result, recent efforts in atlasing these pathways to guide neuromodulation have resorted to using synthetic data. Here we present the first extensive reconstruction of fiber pathways of the human subcortex with ultra-high-resolution dMRI. We leverage a unique,

Indexed as

basal ganglia circuitsDBSdiffusion MRIthalamo-cortical circuitstractography

Identifiers

PMID41959286
PMCPMC13060272

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.