Evidence map›Paper›PMID 41959274›Full record

ArticlebioRxiv : the preprint server for biology2026

A novel mechanism of ceftolozane-tazobactam resistance in

Preeti Garai, Sophia H Nozick, Caroline C Jozefczyk, Hannah Nam, J Nicholas O'Donnell, Egon A Ozer, Alan R Hauser, Nathaniel J Rhodes

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Preeti GaraiDepartment of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
Sophia H NozickDepartment of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0002-0791-6340
Caroline C JozefczykMidwestern University College of Pharmacy Downers Grove Campus, Downers Grove, IL and Department of Pharmacy, Northwestern Medicine, Chicago, IL, USA.
Hannah NamStanford University School of Medicine, Stanford CA, USA.ORCID 0000-0003-4576-287X
J Nicholas O'DonnellDepartment of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, NY, USA.ORCID 0000-0001-5184-1385
Egon A OzerDivision of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0002-7131-3691
Alan R HauserDepartment of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0003-4596-7939
Nathaniel J RhodesDepartment of Pharmacy Practice, Midwestern University College of Pharmacy Downers Grove Campus, Downers Grove, IL, USA.ORCID 0000-0002-0018-5434

Funding

Population Analysis of Pseudomonas aeruginosa VirulenceR01AI118257 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HAUSER, ALAN R · 2016 to 2025
$4.9M
Systems-based pharmacologic modelling to elucidate beta-lactam clinical pharmacodynamics and define optimal dosing regimens in severe pneumoniaR01AI158530 · NIAID · MIDWESTERN UNIVERSITY · PI Nathaniel James Rhodes · 2022 to 2026
$3.4M
NIAID NIH HHS R01 AI118257NIAID NIH HHS R01 AI158530
6 · The paper itself

Abstract

The prevalance of non-susceptibility to ceftolozane-tazobactam (C/T) among

Indexed as

bioinformaticsceftolozane-tazobactamresistancewhole genome sequencingβ-lactamases

Identifiers

PMID41959274
PMCPMC13060818

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.