Evidence map›Paper›PMID 41959271›Full record

ArticlebioRxiv : the preprint server for biology2026

Complementary constraints in germ and immune cells shape evolution of gene regulation and phenotype.

Kimberly N Griffin, Kira L Marshall, Gabriel A Russell, John Attanasio, Delaney B Farris, Haoming Yu, Eric Fagerberg, Nivedita R Iyer, Rebecca Lee, Kaelyn D Sumigray and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kimberly N Griffinequal contribution.ORCID 0000-0002-4073-1989
Kira L Marshallequal contribution.ORCID 0000-0002-8986-9006
Gabriel A Russellequal contribution.ORCID 0000-0002-0729-5628
John AttanasioDepartment of Immunobiology, Yale School of Medicine; New Haven, 06510, USA.
Delaney B FarrisDepartment of Genetics, Yale School of Medicine; New Haven, 06510, USA.ORCID 0000-0002-2378-8326
Haoming YuDepartment of Genetics, Yale School of Medicine; New Haven, 06510, USA.ORCID 0000-0001-6231-7183
Eric FagerbergDepartment of Immunobiology, Yale School of Medicine; New Haven, 06510, USA.
Nivedita R IyerDepartment of Immunobiology, Yale School of Medicine; New Haven, 06510, USA.
Rebecca LeeDepartment of Genetics, Yale School of Medicine; New Haven, 06510, USA.
Kaelyn D SumigrayDepartment of Genetics, Yale School of Medicine; New Haven, 06510, USA.ORCID 0000-0002-1267-7559
Nikhil JoshiDepartment of Immunobiology, Yale School of Medicine; New Haven, 06510, USA.ORCID 0000-0002-7045-7837
Andrew WangDepartment of Internal Medicine (Rheumatology, Allergy, and Immunology), Yale School of Medicine; New Haven, 06510, USA.
Bluma J LeschDepartment of Genetics, Yale School of Medicine; New Haven, 06510, USA.ORCID 0000-0002-6689-0240

Funding

Germline Utx mutation as a model for transgenerational epigenetic inheritanceR01HD098128 · NICHD · YALE UNIVERSITY · PI LESCH, BLUMA J · 2020 to 2024
$2.0M
Defining the role of DOT1L in chromocenter stabilization pre- and post-fertilizationR21HD110843 · NICHD · YALE UNIVERSITY · PI LESCH, BLUMA J · 2023 to 2023
$461k
Defining signatures of epigenetic sensitization to lung cancer in a mouse modelR21CA288677 · NCI · YALE UNIVERSITY · PI LESCH, BLUMA J · 2024 to 2025
$430k
NCI NIH HHS R21 CA288677NICHD NIH HHS R01 HD098128NICHD NIH HHS R21 HD110843
6 · The paper itself

Abstract

New mutations arise in germ cells and must preserve fertility while altering somatic phenotype to confer a fitness advantage. To understand how whole organisms balance these constraints, we generated mice with humanized noncoding promoter sequence at

Identifiers

PMID41959271
PMCPMC13060238

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.