Evidence map›Paper›PMID 41959261›Full record

ArticlebioRxiv : the preprint server for biology2026

Systematic Evaluation Defines the Limits of Ferroptosis in Cancer Therapy.

Kenji M Fujihara, Azmi Aziz, Behnia Akbari, Maria Gutierrez-Perez, Gregory Francis, Siham Zentout, Kameng Wu, Nicholas J Clemons, Erdem M Terzi, Michael E Pacold and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kenji M FujiharaDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Azmi AzizDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Behnia AkbariDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Maria Gutierrez-PerezDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Gregory FrancisDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Siham ZentoutDepartment of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.
Kameng WuDivision of Cancer Research, Peter MacCallum Cancer Centre, Parkville, Victoria, Australia. Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.
Nicholas J ClemonsDivision of Cancer Research, Peter MacCallum Cancer Centre, Parkville, Victoria, Australia. Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.ORCID 0000-0001-9283-9978
Erdem M TerziDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Michael E PacoldLaura & Isaac Perlmutter Cancer Center, New York, NY 10016, USA.
Richard PossematoDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0002-2401-0030

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
Functional Relevance of Pyrimidine Sensing and Response Pathways in Tumor Metabolism and Cancer TherapyR01CA286141 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Richard Lewis Possemato · 2024 to 2026
$2.7M
Regulation Of Metabolism And Gene Expression By Iron-Sulfur Clusters - SupplementR01GM132491 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI POSSEMATO, RICHARD LEWIS · 2020 to 2023
$1.9M
NCI NIH HHS P30 CA016087NCI NIH HHS R01 CA286141NIGMS NIH HHS R01 GM132491
6 · The paper itself

Abstract

Ferroptosis is a cell death mechanism characterized by the accumulation of iron-catalyzed lipid peroxides in membrane lipid acyl chains and subsequent loss of membrane integrity.

Identifiers

PMID41959261
PMCPMC13060917

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.