Evidence map›Paper›PMID 41959244›Full record

ArticlebioRxiv : the preprint server for biology2026

A population-scale atlas of blood and tissue in lupus nephritis.

Nicholas W Sugiarto, Siddarth Gurajala, Michelle Curtis, Thomas M Eisenhaure, Arnon Arazi, Andrea Fava, Qian Xiao, Joseph Mears, Brad Rovin, Celine C Berthier and 35 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

45 authors.

Nicholas W SugiartoCenter for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Siddarth GurajalaCenter for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Michelle CurtisCenter for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Thomas M EisenhaureBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Arnon AraziCenter for Autoimmune, Musculoskeletal and Hematopoietic Diseases, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, USA.
Andrea FavaDivision of Rheumatology, Johns Hopkins University, Baltimore, MD, USA.
Qian XiaoCenter for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Joseph MearsCenter for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Brad RovinOhio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Celine C BerthierInternal Medicine, Department of Nephrology, University of Michigan, Ann Arbor, MI, USA.
Yu ZhaoCenter for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Peter M IzmirlyDepartment of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, USA.
Jennifer L BarnasDepartment of Medicine, Division of Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY, USA.
Paul J HooverBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Michael PetersBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Raktima RaychowdhuryBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Alice HorisbergerDivision of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Saori SakaueCenter for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Richard A FurieDivision of Rheumatology, Northwell Health, Great Neck, NY, USA.
H Michael BelmontDepartment of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, USA.
David A HildemanDepartment of Pediatrics, University of Cincinnati, Cincinnati, OH, USA.ORCID 0000-0002-0421-8483
E Steve WoodleDivision of Transplantation, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Maria Dall'EraRheumatology Division, University of California San Francisco, San Francisco, CA, USA.
Chaim PuttermanDivision of Rheumatology and Department of Microbiology and Immunology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.
Diane L KamenDivision of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA.
Maureen A McMahonDepartment of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Jennifer GrossmanDepartment of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Kenneth C KalunianSchool of Medicine, University of California San Diego, La Jolla, California, USA.
Jeffrey B HodginDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Fernanda Payan-SchoberDepartment of Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA.
William ApruzzesePfizer Inc., New York, NY, USA.
Harris PerlmanDivision of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Carla M CudaDivision of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
David WofsyRheumatology Division, University of California San Francisco, San Francisco, CA, USA.
Joel M GuthridgeArthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.ORCID 0000-0002-9308-237X
Jennifer H AnolikDepartment of Medicine, Division of Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY, USA.ORCID 0000-0002-1450-1549
Judith A JamesArthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Accelerating Medicines Partnerships Rheumatoid Arthritis/Systemic Lupus Erythematosus
Deepak A RaoDivision of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Anne DavidsonCenter for Autoimmune, Musculoskeletal and Hematopoietic Diseases, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, USA.
Michelle A PetriDivision of Rheumatology, Johns Hopkins University, Baltimore, MD, USA.
Jill P BuyonDepartment of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, USA.
Nir HacohenBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Betty DiamondCenter for Autoimmune, Musculoskeletal and Hematopoietic Diseases, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, USA.ORCID 0000-0002-3250-3804
Soumya RaychaudhuriCenter for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-1901-8265

Funding

PEARL: Pathway Exploration and Analysis in Renal LupusUH2AR067688 · NIAMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI DIAMOND, BETTY, WOFSY, DAVID · 2014 to 2020
$9.0M
Tissue Acquisition Research GroupUM2AR067678 · NIAMS · STANFORD UNIVERSITY · PI HOLERS, VERNON MICHAEL, UTZ, PAUL JOSEPH · 2014 to 2020
$8.2M
Multi-Ethnic Translational Research Optimization (METRO) Lupus ConsortiumUH2AR067689 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BUYON, JILL P, PUTTERMAN, CHAIM · 2014 to 2020
$6.3M
Evolving Adaptive and Effector Mechanisms from Pre-RA Through Established DiseaseUH2AR067681 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI HOLERS, VERNON MICHAEL · 2014 to 2020
$5.5M
Molecular and Cellular Dissection of Early Rheumatoid ArthritisUH2AR067694 · NIAMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI BRENNER, MICHAEL B., GREGERSEN, PETER K. · 2014 to 2020
$5.4M
RA-SLE Molecular Deconstruction Leadership CenterUH2AR067677 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI BRENNER, MICHAEL B., RAYCHAUDHURI, SOUMYA · 2014 to 2020
$4.3M
Cellular Dynamics at the Synovium-Bone interface in RAUH2AR067690 · NIAMS · UNIVERSITY OF ROCHESTER · PI ANOLIK, JENNIFER HOWITT · 2014 to 2020
$3.0M
Stanford Technology Accelerating Medicines Partnership CenterUH2AR067676 · NIAMS · STANFORD UNIVERSITY · PI ROBINSON, WILLIAM H, UTZ, PAUL JOSEPH · 2014 to 2020
$2.6M
Accelerating Medicines Partnership in RA and Lupus: Network Sites (UH2/UH3)UH2AR067679 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI PETRI, MICHELLE A · 2014 to 2020
$2.1M
Molecular Pathways in Treatment Response and Flare in RAUH2AR067691 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI BYKERK, VIVIAN P, IVASHKIV, LIONEL B · 2014 to 2020
$2.0M
UPITT Rheumatoid Arthritis Combined Center (UPITT RACC)UH2AR067685 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCGEACHY, MANDY J, MORELAND, LARRY W · 2014 to 2019
$1.2M
NIAMS NIH HHS UH2 AR067676NIAMS NIH HHS UH2 AR067677NIAMS NIH HHS UH2 AR067679NIAMS NIH HHS UH2 AR067681NIAMS NIH HHS UH2 AR067685NIAMS NIH HHS UH2 AR067688NIAMS NIH HHS UH2 AR067689NIAMS NIH HHS UH2 AR067690NIAMS NIH HHS UH2 AR067691NIAMS NIH HHS UH2 AR067694NIAMS NIH HHS UM2 AR067678
6 · The paper itself

Abstract

Lupus nephritis (LN), a severe manifestation of Systemic Lupus Erythematosus (SLE), is a heterogeneous disease driven by diverse immune and tissue cell types. We obtained 538K single-cell and 140K single-nuclear profiles from kidney biopsies of 155 LN patients and 30 pre-implantation transplant biopsy controls, along with 325K single-cell blood profiles overlapping many of these patients. We identified key tissue cell types and cell states, and immune cell states; we were able to determine cell states that were tissue specific, and those that were present in the blood. We observed that LN pathological features are significantly associated with cell states using differential gene expression and Covarying Neighborhood Analysis (CNA). These analyses revealed broad changes in cell states associated with irreversible chronic tissue damage. After controlling for the effects of ongoing tissue damage, we observed that expansion of key glomerular and Scar Associated Macrophages (SAMs) populations tracked with increasing inflammatory disease activity. SAMs appear to drive LN fibrosis and, in active disease, infiltrate the glomeruli more than other myeloid cells. These observations strongly support that therapeutic targeting of myeloid populations may offer an as-of-yet unproven strategy to prevent renal inflammation and ongoing kidney damage in LN.

Identifiers

PMID41959244
PMCPMC13060338

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.