In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
11 authors.
Austin E StisJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.ORCID 0009-0006-3681-3435 Charles S LazimiJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.ORCID 0009-0006-5690-4748 Sandra M FerreiraJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.ORCID 0000-0003-2642-2802 Alexandra E CuaycalJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-9060-6326 Dylan SmurlickJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.ORCID 0000-0003-4551-8885 D Walker HaganJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-8679-1995 Taylor NakayamaDepartment of Neurobiology & Behavior, University of California, Irvine, Irvine, CA, USA.
Sunil P GandhiDepartment of Neurobiology & Behavior, University of California, Irvine, Irvine, CA, USA.
Emery SmithThe Herbert Wertheim UF Scripps Institute Molecular Screening Center, Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL, USA.ORCID 0000-0002-9217-6892 Timothy P SpicerThe Herbert Wertheim UF Scripps Institute Molecular Screening Center, Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL, USA.ORCID 0000-0002-9080-4226 Edward A PhelpsJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.ORCID 0000-0001-8666-805X Funding
Project 3P01AI042288 · NIAID · UNIVERSITY OF FLORIDA · PI Todd Michael Brusko · 1997 to 2026
$32.9MThe Human Islet Distribution Coordinating Center (UC4)UC4DK098085 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI EVANS-MOLINA, CARMELLA, NILAND, JOYCE CAROL · 2012 to 2017
$25.6MEngineering a Human Microphysiological System for the Characterization of Islet-Immune InteractionsUH3DK122638 · NIDDK · UNIVERSITY OF FLORIDA · PI AGARWAL, ASHUTOSH, BRUSKO, TODD MICHAEL · 2021 to 2023
$3.0MLocal immune modulation for beta cell replacement therapy in type 1 diabetesR01DK132387 · NIDDK · UNIVERSITY OF FLORIDA · PI PHELPS, EDWARD, RUSS, HOLGER A. · 2022 to 2025
$2.1MInterdisciplinary Graduate Program in Type 1 Diabetes and Biomedical EngineeringT32DK108736 · NIDDK · UNIVERSITY OF FLORIDA · PI MARK A. ATKINSON, Benjamin George Keselowsky · 2017 to 2026
$1.9MMechanism and dynamics of islet GABA signalingR01DK124267 · NIDDK · UNIVERSITY OF FLORIDA · PI PHELPS, EDWARD · 2021 to 2025
$1.8MRegional and lobular heterogeneity of human pancreas morphology and function in type 1 diabetes pathogenesisR01DK123292 · NIDDK · UNIVERSITY OF FLORIDA · PI ATKINSON, MARK A., SPEIER, STEPHAN · 2020 to 2023
$1.7MNIAID NIH HHS P01 AI042288NIDDK NIH HHS R01 DK123292NIDDK NIH HHS R01 DK124267NIDDK NIH HHS R01 DK132387NIDDK NIH HHS T32 DK108736NIDDK NIH HHS UC4 DK098085NIDDK NIH HHS UH3 DK122638
6 · The paper itselfAbstract
Pancreatic beta cells have the unique function of synthesizing and secreting high amounts of the inhibitory neurotransmitter γ-aminobutyric acid (GABA). The mechanism of GABA secretion, whether vesicular or channel-mediated, is debated. Our study reveals surprising temporal complexity in the pattern of islet GABA secretion. We used insulin secretion modulators to demonstrate that GABA release is not directly correlated with insulin secretion. VGAT reporter mice also showed that beta cells do not express the requisite vesicular GABA transporter (VGAT) for vesicular GABA release. Instead, GABA is secreted from the cytosol in pulses by the LRRC8A/D isoform of the volume regulatory anion channel (VRAC). We further demonstrate the dynamic coordination of GABA release with calcium influx in beta cells and dependence on beta cell depolarization. These results suggest a model where GABA is released during the peaks of beta cell calcium oscillations to provide feedback which strengthens and reinforces the oscillation waveform.
Identifiers
PMID41959232
PMCPMC13060216
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390