Evidence map›Paper›PMID 41959226›Full record

ArticlebioRxiv : the preprint server for biology2026

Multi-omic profiling of human and mouse dorsal root ganglia enables targeted gene delivery to nociceptors.

Lily S He, Parth Bhatia, Shamsuddin A Bhuiyan, Evangelia Semizoglou, Jiaxiang Wang, Jia Li, Joohyun Nam, Jay X J Luo, Chayse Arnhold, Difei Zhu and 14 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Lily S HeDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Parth BhatiaDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Shamsuddin A BhuiyanDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Evangelia SemizoglouDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Jiaxiang WangDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Jia LiDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Joohyun NamDepartment of Anesthesiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Jay X J LuoDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Chayse ArnholdDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Difei ZhuDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Mengyi XuDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Dustin GriesemerDepartment of Anesthesiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Hyo Jeong YongDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Lorna JayneWhitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Evangeline GilmerDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Qiyi LiDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Katerina PantaleoDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Lite YangDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Erika K WilliamsDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Selwyn JayakarDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Brian J WaingerDepartment of Anesthesiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Sinisa HrvatinWhitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
William RenthalDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-0206-2101
NIH PRECISION Human Pain Network

Funding

Spatial Core (Moffit)U19NS130617 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI CLIFFORD J WOOLF · 2022 to 2026
$15.5M
Research Training for AnesthetistsT32GM007592 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI STUART A FORMAN · 1985 to 2026
$11.8M
Central and Peripheral Mechanisms of Corneal PainU01EY034709 · NEI · UNIVERSITY OF NEW ENGLAND · PI Pedram Hamrah, IAN D MENG · 2022 to 2026
$6.4M
Next Generation Gene Therapy for Refractory PainR01NS119476 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI William Russell Renthal · 2022 to 2026
$3.4M
Epigenomic labeling of cells that drive drug abuse behaviorDP1DA054343 · NIDA · BRIGHAM AND WOMEN'S HOSPITAL · PI RENTHAL, WILLIAM RUSSELL · 2021 to 2025
$2.7M
NEI NIH HHS U01 EY034709NIDA NIH HHS DP1 DA054343NIGMS NIH HHS T32 GM007592NINDS NIH HHS R01 NS119476NINDS NIH HHS U19 NS130617
6 · The paper itself

Abstract

Chronic pain conditions are often driven by hyperexcitability of nociceptors, the peripheral sensory neurons that detect noxious stimuli. Recent single-cell transcriptomic studies have begun to clarify the molecular identity of distinct peripheral sensory neuron subtypes, but tools that restrict transgene expression to nociceptors while sparing other dorsal root ganglion (DRG) subtypes remain limited. Here, we combined single-nucleus multi-omic profiling of human and mouse DRG with

Identifiers

PMID41959226
PMCPMC13061087

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.