ArticlebioRxiv : the preprint server for biology2026
ER discontinuities are common in
Kelsey N Mabry, Eric K F Donahue, Aaron D Orgel, Brennen Keuchel, Max G Kushner, Kristopher Burkewitz
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
6 authors.
Kelsey N MabryDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37240, USA.
Eric K F DonahueDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37240, USA.
Aaron D OrgelDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37240, USA.
Brennen KeuchelDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37240, USA.
Max G KushnerDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37240, USA.
Kristopher BurkewitzDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37240, USA.
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3MShop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6MEnhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5MTargeting ER-mitochondrial calcium signaling to promote healthier agingR01AG073354 · NIA · VANDERBILT UNIVERSITY · PI Kristopher Burkewitz · 2022 to 2026
$1.6MTargeting mechanisms of inter-organelle communication to promote healthy agingR00AG052666 · NIA · VANDERBILT UNIVERSITY · PI BURKEWITZ, KRISTOPHER · 2019 to 2021
$726kElucidating the role of ER remodeling in aging of C. elegansF31AG076290 · NIA · VANDERBILT UNIVERSITY · PI DONAHUE, ERIC KF · 2022 to 2024
$118kNCI NIH HHS P30 CA068485NEI NIH HHS P30 EY008126NIA NIH HHS F31 AG076290NIA NIH HHS R00 AG052666NIA NIH HHS R01 AG073354NIDDK NIH HHS P30 DK058404NIGMS NIH HHS T32 GM007347NIH HHS P40 OD010440
6 · The paper itselfAbstract
The neuronal endoplasmic reticulum (ER) extends from the soma into axons and dendrites to coordinate protein trafficking, lipid metabolism, inter-organelle organization, and calcium homeostasis. Conserved genes involved in shaping the tubular ER are implicated in neurodevelopment and neurodegeneration, suggesting that ER structure and dynamics influence neuronal health and drive pathogenesis. However, the links between ER morphology and neuronal function and resilience remain incompletely understood. While models typically depict the neuronal ER as a fully continuous network, here we show that micron-scale ER discontinuities in neurites are unexpectedly common in young, unstressed
Identifiers
PMID41959216
PMCPMC13060194
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