ArticlebioRxiv : the preprint server for biology2026
Endocytosis at the mouse blood brain barrier is elevated during sleep.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
3 authors.
Funding
Abstract
Sleep is thought to be important for the clearance of brain waste, but exactly how it does so is still debated. Here, we demonstrate that endocytosis in brain endothelial cells (BECs) of the blood-brain barrier (BBB) is enhanced during sleep, facilitating the removal of brain-derived waste, including amyloid-β, into the circulation. Using proteomics, in vivo tracer imaging, and endothelial-specific genetic perturbations in mice, we demonstrate that sleep enhances endocytic vesicle formation and cargo transcytosis in brain endothelial cells (BECs). Conversely, blocking endocytosis through endothelial Dnm2 knockout suppresses BEC-mediated transport and elevates sleep need, revealing a causal feedback loop between sleep and vascular endocytosis. These findings identify BBB endocytosis as a key sleep-dependent clearance pathway with implications for neurodegenerative disease.
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Registered trials
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