Evidence map›Paper›PMID 41959207›Full record

ArticlebioRxiv : the preprint server for biology2026

Rise-and-fall dynamics reveal a molecular and cellular vulnerability axis in prion-like

Christoffer G Alexandersen, Julia K Brynildsen, Alice Prigent, Massimiliano Tamborrino, Anastasia Mantziou, Kevin Kurgat, Michael X Henderson, Dani S Bassett

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christoffer G AlexandersenDepartment of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, PA, USA.ORCID 0000-0002-9645-7552
Julia K BrynildsenDepartment of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, PA, USA.ORCID 0000-0002-1627-6576
Alice PrigentAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD.
Massimiliano TamborrinoDepartment of Statistics, University of Warwick, Warwick, UK.ORCID 0000-0002-4661-8071
Anastasia MantziouDepartment of Statistics, University of Warwick, Warwick, UK.ORCID 0000-0002-2762-023X
Kevin KurgatAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD.ORCID 0000-0003-3237-7390
Michael X HendersonAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD.
Dani S BassettDepartment of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, PA, USA.ORCID 0000-0002-6183-4493

Funding

Network and cellular vulnerability to pathological protein progressionR01AG077573 · NIA · VAN ANDEL RESEARCH INSTITUTE · PI Michael Henderson · 2022 to 2026
$2.2M
NIA NIH HHS R01 AG077573
6 · The paper itself

Abstract

The spread of misfolded proteins through neuronal circuits is a defining feature of neurodegenerative disease, yet the dynamics underlying this process remain poorly understood. Most studies rely on sparsely sampled datasets that capture spatial patterns of pathology but not their temporal evolution. Here, we analyze longitudinal histopathology measurements of

Identifiers

PMID41959207
PMCPMC13060082

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.