ArticlebioRxiv : the preprint server for biology2026
c-MYC is an aggregation-prone, amyloidogenic protein.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
3 authors.
Funding
Abstract
The transcription factor c-MYC is a central regulator of diverse biological processes and an oncogenic driver. Paradoxically, c-MYC also exhibits intrinsic tumor-suppressive activity through apoptosis, a phenomenon known as the "c-MYC paradox". Here, we identify c-MYC as an intrinsically amyloidogenic protein. Under proteotoxic stress, c-MYC becomes detergent-insoluble aggregates. Notably, even in the absence of stress, c-MYC assembles into soluble amyloid-like oligomers in human cancer tissues and Alzheimer's disease brains.
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Registered trials
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