Evidence map›Paper›PMID 41959192›Full record

ArticlebioRxiv : the preprint server for biology2026

The Human Male Mammary Gland has Similar Epithelial Populations to Female but Distinct Composition and Transcriptional Properties.

M-Iliana Ibañez-Rios, Syed Mohammed Musheer Aalam, Megan L Ritting, Ashlyn Jore, Keyur Chaludia, Chitra Priya Emperumal, James W Jakub, Sarah A McLaughlin, Amy C Degnim, Judy C Boughey and 7 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

M-Iliana Ibañez-RiosInstitut de Recherche en Immunologie et Cancérologie, and Département de Pathologie et Biologie Cellulaire, Université de Montréal, Montreal, QC, Canada.
Syed Mohammed Musheer AalamDivision of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-8566-197X
Megan L RittingDivision of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-8532-2102
Ashlyn JoreDivision of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Keyur ChaludiaDivision of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Chitra Priya EmperumalDivision of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-9208-9406
James W JakubDivision of Surgical Oncology, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0002-8005-1072
Sarah A McLaughlinDivision of Surgical Oncology, Mayo Clinic, Jacksonville, FL, USA.
Amy C DegnimDivision of Breast and Melanoma Surgical Oncology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-2303-4946
Judy C BougheyDivision of Breast and Melanoma Surgical Oncology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-3820-3228
Fergus J CouchDivision of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-9417-9985
Siddhartha YadavDepartment of Oncology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-4630-9903
Anguraj SadanandamDivision of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-8485-5150
Mark E ShermanDepartment of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0002-9222-8808
Derek RadiskyDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0002-1962-8784
David J H F KnappInstitut de Recherche en Immunologie et Cancérologie, and Département de Pathologie et Biologie Cellulaire, Université de Montréal, Montreal, QC, Canada.ORCID 0000-0002-2161-9959
Nagarajan KannanDivision of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-8825-2178

Funding

The Role of CHFR in Tumorigenesis and Paclitaxel-Sensitivity in Breast CancerP50CA116201 · NCI · MAYO CLINIC ROCHESTER · PI PETER C LUCAS · 2005 to 2026
$49.9M
Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancerP50CA136393 · NCI · MAYO CLINIC ROCHESTER · PI SCOTT H KAUFMANN · 2009 to 2026
$37.0M
Resolving the cancer relevance of predisposition gene mutationsR35CA253187 · NCI · MAYO CLINIC ROCHESTER · PI Fergus Joseph Couch · 2020 to 2026
$5.8M
Predoctoral Training Program in Molecular PharmacologyT32GM144233 · NIGMS · MAYO CLINIC ROCHESTER · PI DOO-SUP CHOI · 2022 to 2026
$1.5M
NCI NIH HHS P50 CA116201NCI NIH HHS P50 CA136393NCI NIH HHS R35 CA253187NIGMS NIH HHS T32 GM144233
6 · The paper itself

Abstract

The normal adult male breast has not been characterized at single-cell resolution, leaving the cellular basis of male breast cancer (MBC) biology undefined. Here we present an integrated single-cell RNA sequencing atlas of the adult human breast comprising 174,471 cells from 17 donors (3 male, 14 female), including 18,117 male-derived cells. This revealed that the male breast retains all three epithelial populations, basal (BC), luminal progenitor (LP), and luminal committed cells (LC), but with an increase in LC at the expense of BC and LP across all three male donors. Male LC were distinguished from female by elevated

Identifiers

PMID41959192
PMCPMC13060133

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.