Evidence map›Paper›PMID 41959189›Full record

ArticlebioRxiv : the preprint server for biology2026

Targeted Magnetic Nanodiscs for Wireless Causal Manipulation of Gut-Brain Circuits.

Ye Ji Kim, Nasim Biglari, Taylor M Cannon, Cameron Forbrigger, Scott Machen, Emmanuel Vargas Paniagua, Karen K L Pang, Jessica Slaughter, Jacob L Beckham, Keisuke Nagao and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ye Ji KimDepartment of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-1170-6119
Nasim BiglariResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Taylor M CannonResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Cameron ForbriggerMedical Microsystems Lab, Institute for Translational Medicine, ETH Zurich, 8092 Zurich, Switzerland.
Scott MachenResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Emmanuel Vargas PaniaguaResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Karen K L PangResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Jessica SlaughterDepartment of Computer Science and Electrical Engineering, University of Maryland, Baltimore County.
Jacob L BeckhamResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Keisuke NagaoDepartment of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0009-0002-2296-1817
Elizabeth WhittierResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Florian KoehlerResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Rebecca LeomiResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Polina AnikeevaDepartment of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-6495-5197

Funding

Fusion of nanomagnetic and viral tools to interrogate brain-body circuitsDP1AT011991 · NCCIH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ANIKEEVA, POLINA O · 2021 to 2025
$5.3M
A multifunctional fiber platform for wireless, volumetric imaging and modulation of neural activity in vivoF32MH139162 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CANNON, TAYLOR MARIE · 2024 to 2025
$162k
NCCIH NIH HHS DP1 AT011991NIMH NIH HHS F32 MH139162
6 · The paper itself

Abstract

Causal manipulation of gut-brain neural circuits empowers studies of metabolism and interoception. However, the anatomy and cytoarchitecture of peripheral ganglia relaying gut-brain circuits pose challenges to deployment of optical or electrical stimulation probes. To enable implant-free, cell-type specific, and temporally precise control of defined gut-brain pathways, we develop a neuromodulation platform based on magnetic nanodiscs (MNDs) targeted to peripheral neurons via genetically delivered anchoring moieties. The anchored MNDs selectively transduce externally applied weak magnetic fields to mechanical torque, thereby activating endogenous mechanosensitive pathways in specified cell types with sub-second latency. When targeted to nodose ganglia neurons expressing oxytocin or glucagon-like peptide 1 receptors, MND-mediated stimulation enables robust and reversible activation of gut-brain signaling, which engages hindbrain satiety circuits and regulates feeding behavior. These findings establish MND-mediated stimulation as a genetically targetable, implant-free strategy for modulating gut-brain neural circuits and highlight its potential in studies of brain-body physiology and bioelectronic medicines.

Identifiers

PMID41959189
PMCPMC13060221

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.