Evidence map›Paper›PMID 41959148›Full record

ArticlebioRxiv : the preprint server for biology2026

Functional genomics reveals mediators of beta cell survival in ER stress and type 2 diabetes risk.

Mei-Lin Okino, Han Zhu, Sierra Corban, Paola Benaglio, Jovina Djulamsah, Bailey O'Mahony, Kennedy Vanderstel, Ruth Elgamal, Michael Miller, Allen Wang and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mei-Lin OkinoBiomedical Sciences graduate program, University of California San Diego, La Jolla CA.
Han ZhuDepartment of Pediatrics, University of California San Diego, La Jolla CA.
Sierra CorbanBiomedical Sciences graduate program, University of California San Diego, La Jolla CA.
Paola BenaglioDepartment of Pediatrics, University of California San Diego, La Jolla CA.
Jovina DjulamsahDepartment of Pediatrics, University of California San Diego, La Jolla CA.
Bailey O'MahonyBiomedical Sciences graduate program, University of California San Diego, La Jolla CA.
Kennedy VanderstelBiomedical Sciences graduate program, University of California San Diego, La Jolla CA.
Ruth ElgamalBiomedical Sciences graduate program, University of California San Diego, La Jolla CA.
Michael MillerCenter for Epigenomics, University of California San Diego, La Jolla CA.
Allen WangCenter for Epigenomics, University of California San Diego, La Jolla CA.
Maike SanderDepartment of Pediatrics, University of California San Diego, La Jolla CA.
Kyle GaultonDepartment of Pediatrics, University of California San Diego, La Jolla CA.

Funding

The impact of genomic variation on environment-induced changes in pancreatic beta cell statesU01HG012059 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Hannah Kathryn Carter, Kyle Jeffrie Gaulton · 2021 to 2026
$7.5M
Genetic mechanisms of type 1 diabetes risk in stress-induced pancreatic isletsR01DK122607 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GAULTON, KYLE JEFFRIE · 2019 to 2022
$4.4M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
NHGRI NIH HHS U01 HG012059NIDDK NIH HHS R01 DK122607NIH HHS S10 OD026929
6 · The paper itself

Abstract

Endoplasmic reticulum (ER) stress in pancreatic beta cells contributes to impaired function and type 2 diabetes (T2D). In this study we performed genome-wide perturbation screens and genomic profiling in beta cells to identify novel mediators of ER stress responses and diabetes risk. We defined gene regulatory networks in beta cells and identified specific beta cell networks enriched for T2D risk variants with altered expression in ER stress. We performed a loss-of-function CRISPR screen for survival under ER stress in EndoC-βH1 cells, which identified 167 pro-survival and 47 pro-death genes involved in processes related to insulin secretion, mitochondrial transport and protein ubiquitination. Beta cell survival genes collectively had limited genomic change in stress yet showed significant, independent enrichment for T2D risk variants, including novel T2D candidate gene

Identifiers

PMID41959148
PMCPMC13060215

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.