Evidence map›Paper›PMID 41959146›Full record

ArticlebioRxiv : the preprint server for biology2026

Fatty acid scavenging enables cancer escape from KRAS inhibition.

Zihang Yuan, Bo Lin, Chunlan Wang, Yingying Miao, Da Zhang, Ziru Meng, Gangqi Wang, Andrew M Lowy, Michael Karin, Fei Yang and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zihang YuanInstitutes of Biomedical Sciences, Fudan University, Shanghai, China.
Bo LinInstitutes of Biomedical Sciences, Fudan University, Shanghai, China.
Chunlan WangInstitutes of Biomedical Sciences, Fudan University, Shanghai, China.
Yingying MiaoInstitutes of Biomedical Sciences, Fudan University, Shanghai, China.
Da ZhangInstitutes of Biomedical Sciences, Fudan University, Shanghai, China.
Ziru MengInstitutes of Biomedical Sciences, Fudan University, Shanghai, China.
Gangqi WangInstitutes of Biomedical Sciences, Fudan University, Shanghai, China.
Andrew M LowyDepartment of Surgery, Division of Surgical Oncology, University of California, San Diego Moores Cancer Center, La Jolla, CA, USA.
Michael KarinCenter for Metabolic and Liver Diseases, SBP Medical Discovery Institute, La Jolla, CA, USA.
Fei YangDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Beicheng SunDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Hua SuInstitutes of Biomedical Sciences, Fudan University, Shanghai, China.ORCID 0000-0003-2344-3886

Funding

The effect of cancer cell produced collagen 1 homotrimers on DDR1 signaling activation by microenvironmental collagen 1 fragments.U01CA274295 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Michael Karin, ANDREW M LOWY · 2022 to 2026
$5.2M
Collagen fibers and fragments regulate pancreatic cancer metabolism and growth.R01CA285997 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAVID A. BRENNER, Michael Karin · 2024 to 2026
$2.2M
NCI NIH HHS R01 CA285997NCI NIH HHS U01 CA274295
6 · The paper itself

Abstract

Although inhibitors of oncogenic KRAS have shown clinical efficacy

Identifiers

PMID41959146
PMCPMC13060362

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.