Evidence map›Paper›PMID 41959134›Full record

ArticlebioRxiv : the preprint server for biology2026

Combined Menin and XPO1 inhibition drive synergistic antileukemic activity in

Md Hafiz Uddin, Sandhya Dhiman, Yufen Han, Amro Aboukameel, Vikram Dhillon, Jeff Aguillar, Steven Buck, Abhinav Deol, Julie L Boerner, Lisa Polin and 8 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Md Hafiz UddinDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI.ORCID 0000-0002-0188-6857
Sandhya DhimanDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI.
Yufen HanDepartment of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Amro AboukameelDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI.
Vikram DhillonDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI.
Jeff AguillarDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI.
Steven BuckDivision of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Detroit, MI.
Abhinav DeolDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI.
Julie L BoernerDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI.
Lisa PolinDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI.
Linda KesslerKura Oncology, San Diego, CA 92130.
Francis BurrowsKura Oncology, San Diego, CA 92130.
Jay YangDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI.
Asfar S AzmiDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI.
Jaroslaw P MaciejewskiTranslational Hematology and Oncology Research, Cleveland Clinic Foundation/ Taussig Cancer Institute, Cleveland, OH.
Jevon CutlerOregon Health & Science University (OHSU), Portland, Oregon.
Yang DuDepartment of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Suresh Kumar BalasubramanianDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI.

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI Julie Lynn Boerner · 1985 to 2026
$68.4M
NCI NIH HHS P30 CA022453
6 · The paper itself

Abstract

Menin scaffolds the oncogenic histone-lysine-N-methyltransferase (KMT2A)-fusion protein (FP) complex in

Indexed as

MeninMLLr/KMT2A-r/NPM1-m AMLnuclear exportsynergistic combination

Identifiers

PMID41959134
PMCPMC13060913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.