Evidence map›Paper›PMID 41959082›Full record

ArticlebioRxiv : the preprint server for biology2026

Shape Factor Analysis as a Quantitative Framework for Assessing Spheroid and Organoid Morphology and Invasiveness.

Brittany E Schutrum, Jenny Deng, Ju Hee Kim, Amalie Gao, Emily Hur, Jack C Crowley, Lu Ling, Matalin G Pirtz, Coulter Q Ralston, Alexander Yu Nikitin and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Brittany E SchutrumNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.ORCID 0000-0002-4462-7812
Jenny DengNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.ORCID 0009-0007-0925-3281
Ju Hee KimNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Amalie GaoNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Emily HurNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Jack C CrowleySchool of Applied Engineering Physics, Cornell University, Ithaca, NY, USA.ORCID 0000-0003-4220-8152
Lu LingNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.ORCID 0000-0001-6693-8665
Matalin G PirtzNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.ORCID 0000-0002-5668-3061
Coulter Q RalstonNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.ORCID 0000-0003-2093-6482
Alexander Yu NikitinDepartment of Biomedical and Translational Sciences, Cornell University, Ithaca, NY, USA.ORCID 0000-0002-3729-7982
Claudia FischbachNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.ORCID 0000-0002-9368-0150

Funding

Mechanical properties of adipose tissue and its effect on breast cancerR01CA276392 · NCI · CORNELL UNIVERSITY · PI Claudia Fischbach, Corey O'Hern · 2023 to 2026
$2.1M
Endometrial epithelial stem cells and cancerR01CA248524 · NCI · CORNELL UNIVERSITY · PI NIKITIN, ALEXANDER Y. · 2021 to 2025
$2.1M
Cancer-prone cell states of the fallopian tubal epitheliumR01CA260115 · NCI · CORNELL UNIVERSITY · PI NIKITIN, ALEXANDER Y. · 2021 to 2025
$2.1M
Metabolic regulation of exosome biogenesis as a determinant of cancer cell metastasis.R01CA259195 · NCI · CORNELL UNIVERSITY · PI MARC A ANTONYAK, Claudia Fischbach · 2022 to 2026
$2.1M
The integrated mechanobiology and glycobiology of bone metastasisR01CA297166 · NCI · CORNELL UNIVERSITY · PI Claudia Fischbach, Matthew J Paszek · 2025 to 2026
$1.2M
Broad wavelength range Zeiss 780 NLO/confocal system for the Cornell Imaging CoreS10OD018516 · OD · CORNELL UNIVERSITY · PI ZIPFEL, WARREN R · 2014 to 2014
$834k
Zeiss LSM710 Confocal Microscope for Shared Imaging FacilityS10RR025502 · NCRR · CORNELL UNIVERSITY · PI WILLIAMS, REBECCA M · 2009 to 2009
$500k
NCI NIH HHS R01 CA248524NCI NIH HHS R01 CA259195NCI NIH HHS R01 CA260115NCI NIH HHS R01 CA276392NCI NIH HHS R01 CA297166NCRR NIH HHS S10 RR025502NIH HHS S10 OD018516
6 · The paper itself

Abstract

Morphological changes of spheroids and organoids are widely used as

Identifiers

PMID41959082
PMCPMC13060997

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.