Evidence map›Paper›PMID 41959069›Full record

ArticlebioRxiv : the preprint server for biology2026

Genetic dissection of rapid proteolysis identifies TXNDC15 as a key factor of ERAD and lipid homeostasis.

Yuyang Liu, Michelle Yinfei Yaochai, Shanshan Liu, Hanan Alwaseem, Kivanc Birsoy

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuyang LiuLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.
Michelle Yinfei YaochaiLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.
Shanshan LiuLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.
Hanan AlwaseemThe Proteomics Resource Center, The Rockefeller University, New York, NY, USA.
Kivanc BirsoyLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.

Funding

The physiological and molecular function of choline transport in health and metabolic diseaseR01DK140337 · NIDDK · ROCKEFELLER UNIVERSITY · PI Kivanc Birsoy · 2024 to 2026
$2.2M
The role of mitochondrial glutathione homeostasis in tumor formationR01CA273233 · NCI · ROCKEFELLER UNIVERSITY · PI Kivanc Birsoy · 2023 to 2026
$1.9M
Dissecting the role of mitochondrial glutathione homeostasis in cancerF99CA284249 · NCI · ROCKEFELLER UNIVERSITY · PI LIU, YUYANG · 2023 to 2024
$98k
NCI NIH HHS F99 CA284249NCI NIH HHS R01 CA273233NIDDK NIH HHS R01 DK140337
6 · The paper itself

Abstract

Biological systems face a constantly changing environment and must swiftly respond to stimuli, yet how cells sense and adapt to environmental and physiological cues is incompletely understood. Short-lived proteins can be rapidly induced upon perturbation, enabling swift activation of adaptive cellular responses. Leveraging genome-wide data on protein-transcript correlation, we systematically searched for rapid proteolysis substrates whose abundance reflects the activity of the underlying proteolytic machinery. Here, focusing on the candidate substrate ABHD2, we employed CRISPR-based functional screens to dissect its degradation and identified

Identifiers

PMID41959069
PMCPMC13060290

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.