Evidence map›Paper›PMID 41959052›Full record

ArticlebioRxiv : the preprint server for biology2026

Disrupting FOXO4 function confers neuroprotection against oxidative stress and ischemia-reperfusion-caused neuronal injury.

Yasin Asadi, Farhad Gorjipour, Rozenn K Moundounga, Abena Dwamena, Augustina Potokiri, Erin Gilstrap, Xiaoping Li, Caroline McDowell, Hongmin Wang

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Yasin AsadiDepartment of Pharmacology and Neuroscience, Garrison Institute on Aging, and Center of Excellence for Translational Neuroscience and Therapeutics, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, Texas 79430-6592, USA.ORCID 0009-0004-9222-6206
Farhad GorjipourDepartment of Pharmacology and Neuroscience, Garrison Institute on Aging, and Center of Excellence for Translational Neuroscience and Therapeutics, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, Texas 79430-6592, USA.
Rozenn K MoundoungaDepartment of Pharmacology and Neuroscience, Garrison Institute on Aging, and Center of Excellence for Translational Neuroscience and Therapeutics, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, Texas 79430-6592, USA.
Abena DwamenaDepartment of Pharmacology and Neuroscience, Garrison Institute on Aging, and Center of Excellence for Translational Neuroscience and Therapeutics, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, Texas 79430-6592, USA.
Augustina PotokiriDepartment of Pharmacology and Neuroscience, Garrison Institute on Aging, and Center of Excellence for Translational Neuroscience and Therapeutics, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, Texas 79430-6592, USA.
Erin GilstrapDepartment of Pharmacology and Neuroscience, Garrison Institute on Aging, and Center of Excellence for Translational Neuroscience and Therapeutics, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, Texas 79430-6592, USA.
Xiaoping LiDivisioin of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA.
Caroline McDowellProgram in Biochemistry and Biocomputational Engineering, Lehigh University, Bethlehem, PA 18015, USA.
Hongmin WangDepartment of Pharmacology and Neuroscience, Garrison Institute on Aging, and Center of Excellence for Translational Neuroscience and Therapeutics, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, Texas 79430-6592, USA.ORCID 0000-0002-0392-4458

Funding

FOXOs in ischemic strokeR01NS124846 · NINDS · UNIVERSITY OF SOUTH DAKOTA · PI Hongmin Wang · 2022 to 2026
$1.9M
NINDS NIH HHS R01 NS124846
6 · The paper itself

Abstract

Previous data suggest that FOXO4 facilitates inflammation and oxidative stress in

Indexed as

FOXO4ischemiaknockoutneuroprotectionreperfusionstroke

Identifiers

PMID41959052
PMCPMC13060933

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.