Evidence map›Paper›PMID 41959015›Full record

ArticlebioRxiv : the preprint server for biology2026

Efficient Generation of Functional TCRαβ

Caroline Kubaczka, Netra Kambli, Roland Windisch, Kelly Yu, Yunliang Zhao, Sharon Wu, Katie Frenis, Morgan T Walcheck, Marcelo Falchetti, Mohamad Najia and 5 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Caroline KubaczkaStem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-7783-6602
Netra KambliStem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0009-0009-4954-1127
Roland WindischStem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0003-1294-5151
Kelly YuStem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.
Yunliang ZhaoStem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.
Sharon WuStem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.
Katie FrenisStem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.
Morgan T WalcheckStem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.
Marcelo FalchettiStem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-9438-680X
Mohamad NajiaStem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-2558-8846
Zachary C LeBlancStem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-1662-2846
Trista E NorthStem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0003-1249-563X
R Grant RoweStem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.
George Q DaleyStem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.
Thorsten M SchlaegerStem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.

Funding

Molecular Circuits in the Hematopoietic Stem Cell NicheRC2DK120535 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI COLLINS, JAMES J, DALEY, GEORGE Q · 2020 to 2024
$8.2M
Developmental Activation of the Inflammasome Controls Hematopoietic Stem Cell ProductionR01HL154580 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI NORTH, TRISTA E. · 2020 to 2023
$2.2M
Control of hematopoietic maturation by Lin28b/let-7R01DK134515 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI Robert Grant Rowe · 2022 to 2026
$1.8M
NHLBI NIH HHS R01 HL154580NIDDK NIH HHS R01 DK134515NIDDK NIH HHS RC2 DK120535
6 · The paper itself

Abstract

Genetically engineered human induced pluripotent stem cells (hiPSCs) represent a promising platform for regenerative medicine and next-generation immunotherapies. While recent advances enable stroma-free differentiation of hiPSCs into mature CD3

Indexed as

Aryl hydrocarbon receptor (AHR)autoimmune diseasecancer immunotherapyCAR-T cellschemical screencytotoxic T cellsDOT1LGSKhematopoiesislymphoid developmentpluripotent stem cellsT cell differentiationWNT

Identifiers

PMID41959015
PMCPMC13060064

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.