Evidence map›Paper›PMID 41959013›Full record

ArticlebioRxiv : the preprint server for biology2026

Determinants of metal import and specificity in a bacterial transporter.

Samuel P Berry, Camille B Freedman, Debora S Marks, Rachelle Gaudet

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Samuel P BerryDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA USA.ORCID 0000-0002-3480-5988
Camille B FreedmanDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA USA.ORCID 0000-0001-9011-5060
Debora S MarksDepartment of Systems Biology, Harvard Medical School, Boston, MA USA.ORCID 0000-0001-9388-2281
Rachelle GaudetDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA USA.ORCID 0000-0002-9177-054X

Funding

MOLECULAR BIOPHYSICS TRAINING GRANTT32GM008313 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MURTHY, VENKATESH N · 1989 to 2023
$14.6M
Making antibody generation rapid, scalable, and democratic through machine learning and continuous evolutionR01CA260415 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI KRUSE, ANDREW, LIU, CHANG C · 2020 to 2024
$8.4M
Mechanism of Divalent Metal Transport by NRamp-Family TransportersR01GM120996 · NIGMS · HARVARD UNIVERSITY · PI GAUDET, RACHELLE · 2017 to 2024
$3.0M
NCI NIH HHS R01 CA260415NIGMS NIH HHS R01 GM120996NIGMS NIH HHS T32 GM008313
6 · The paper itself

Abstract

Membrane transporters have evolved finely tuned substrate specificity within a limited repertoire of structural superfamilies, but the biophysical origins of transporter specificity remain unclear. We have systematically investigated the determinants of import and specificity in the model

Identifiers

PMID41959013
PMCPMC13060092

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.