ReviewFrontiers in pharmacology2026
Exploring the therapeutic potential of naturally occurring taxifolin, a dietary flavonoid: an updated comprehensive review.
Review in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Flavonoids, well-known as key bioactive compounds in numerous medicinal plants, help protect these plants against both biotic and abiotic stresses and are linked to the prevention of various degenerative diseases. The diverse pharmacological effects and therapeutic potential of flavonoids are influenced by factors such as their level of hydroxylation, structural classification, additional substitutions and conjugations, extent of polymerization, and their ability to chelate metals. Methods: Data from various databases such as the Egyptian Knowledge Bank (EKB), Scopus, Web of Science, PubMed, Google Scholar, and Elsevier databases were gathered until April 2025. All possible keywords pertaining to taxifolin, natural origins, isolation, structure, solubility, synthesis, bioavailability, applications, biological activities, mechanisms of actions, pharmacokinetics, and clinical studies were utilized in the search. Results: Taxifolin, a bioactive flavonoid commonly found in dietary sources such as onions, milk thistle, and Douglas fir bark, has garnered significant attention for its extensive health-promoting properties. It exhibits potent antioxidant, anti-inflammatory, anticancer, antimicrobial, cardioprotective, neuroprotective, and hepatoprotective effects. Notably, taxifolin demonstrates superior antioxidant capacity linked to its phenolic hydroxyl groups and structural features, enabling effective free radical scavenging. Conclusion: Despite these promising pharmacological activities, further research is necessary to elucidate its detailed molecular mechanisms, pharmacokinetic profile, and comprehensive safety through well-designed randomized clinical trials to facilitate its development as a therapeutic agent for human use.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.