Evidence map›Paper›PMID 41958928›Full record

ArticleFrontiers in pharmacology2026

Successful treatment of primary mediastinal malignant germ cell tumor with multiple systemic metastases in children using multi-drug combination chemotherapy: a rare case report.

Yang-Yang Jiao, Yan-Hua Li, Xue-Lian Liao, Jing-Bo Shao, Ting Zhang, Jing-Wei Yang, Can Huang, Wen-Yan Huang, Sha-Yi Jiang

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yang-Yang JiaoDepartment of Hematology and Oncology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.
Yan-Hua LiDepartment of Hematology and Oncology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.
Xue-Lian LiaoDepartment of Hematology and Oncology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.
Jing-Bo ShaoDepartment of Hematology and Oncology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.
Ting ZhangDepartment of Hematology and Oncology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.
Jing-Wei YangDepartment of Hematology and Oncology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.
Can HuangDepartment of Hematology and Oncology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.
Wen-Yan HuangDepartment of Nephrology, Rheumatology and Immunology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Sha-Yi JiangDepartment of Hematology and Oncology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary mediastinal malignant germ cell tumors (PMMGCTs) in children are highly aggressive and associated with a poor prognosis. We herein report the case of a male pediatric patient who presented with a large mediastinal mass and extensive metastases to the lungs, brain, kidneys, and multiple bones, illustrating the aggressive nature of this disease. The patient received a multi-drug combination chemotherapy regimen before and after tumor resection and successfully achieved complete remission. Notably, he has survived for 12 months and remains in complete remission to date. This case underscores the potential efficacy of multi-agent combination chemotherapy as a component of a multimodal treatment strategy for advanced PMMGCTs.

Indexed as

case reportchildrenmalignant germ cell tumormediastinaltreatment

Identifiers

PMID41958928
PMCPMC13057388

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