ReviewBrain communications2026
Ferroptosis in microglial activation: a systematic review and multidata comparison.
Review in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Ferroptosis in major depressive disorder: Molecular mechanisms, cellular vulnerability, and therapeutic opportunities.Biochemistry and biophysics reports · 2026Review
- APOE4 Drives Uniquely Dysfunctional Human Microglial States in Alzheimer's Disease.bioRxiv : the preprint server for biology · 2026Article
- Iron-driven secondary injury after intracranial hemorrhage: mitochondrial dysfunction and ferroptosis.Frontiers in neuroscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ferroptosis is a redox-driven and iron-dependent type of programmed cell death, with lipid peroxidation as a central and required feature of the process. During ferroptosis, cells exert strong proinflammatory effects, suggesting that ferroptosis may play a role in the regulation of inflammation and immune response. However, very few studies have investigated the process of ferroptosis and lipid peroxidation in microglia, the innate immune cells of the brain. In this review, we summarize the concept of ferroptosis and present a list of 120 ferroptosis-relevant proteins, which includes over twice as many entries as the current Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway for ferroptosis. We compare our manually compiled list with microglial activation signatures reported by us and others, revealing ferroptosis-relevant changes in models for microglial activation. Finally, we highlight a selection of ferroptosis-relevant proteins as potential biomarker candidates for ferroptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.