Evidence map›Paper›PMID 41958917›Full record

ArticleBrain communications2026

Amygdala TDP-43 pathology is associated with behavioural dysfunction and ferritin accumulation in amyotrophic lateral sclerosis.

Olivia M Rifai, Fergal M Waldron, Judi O'Shaughnessy, Fiona L Read, Martina Gilodi, Annalisa Pastore, Neil A Shneider, Gian Gaetano Tartaglia, Elsa Zacco, Holly Spence and 1 more

Abstract read
In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Olivia M RifaiCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.
Fergal M WaldronInstitute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Judi O'ShaughnessyDepartment of Chemistry, University of Edinburgh, Edinburgh EH9 3FJ, UK.
Fiona L ReadInstitute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Martina GilodiRNA System Biology Lab, Center for Human Technology, Istituto Italiano di Tecnologia, Genoa 16152, Italy.
Annalisa PastoreThe Maurice Wohl Institute, King's College London, London SE5 9RT, UK.
Neil A ShneiderDepartment of Neurology, Center for Motor Neuron Biology and Disease, Columbia University, NewYork 10032, USA.
Gian Gaetano TartagliaRNA System Biology Lab, Center for Human Technology, Istituto Italiano di Tecnologia, Genoa 16152, Italy.ORCID https://orcid.org/0000-0001-7524-6310
Elsa ZaccoRNA System Biology Lab, Center for Human Technology, Istituto Italiano di Tecnologia, Genoa 16152, Italy.
Holly SpenceInstitute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Jenna M GregoryInstitute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.

Funding

The Physical Biology of Neurodegeneration in Sporadic Amyotrophic Lateral Sclerosis/Frontotemporal DementiaR01NS127186 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HOLT, LIAM J, PHATNANI, HEMALI · 2021 to 2025
$8.2M
NINDS NIH HHS R01 NS127186Wellcome Trust
6 · The paper itself

Abstract

Cognitive and behavioural symptoms associated with amyotrophic lateral sclerosis and frontotemporal spectrum disorders (ALS-FTSD) are thought to be driven, at least in part, by the pathological accumulation of TDP-43. Here we examine

Indexed as

ALSbehaviourcognitionECASTDP-43

Identifiers

PMID41958917
PMCPMC13056708

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.