Evidence map›Paper›PMID 41958885›Full record

ArticleFrontiers in endocrinology2026

Maternal and neonatal vitamin D metabolite profiling and its long-term impact on childhood growth: findings from the KLOTHO birth cohort.

Spyridon N Karras, Maria Kypraiou, Vikentia Harizopoulou, Antonios Vlastos, Marios Anemoulis, Maria Dalamaga, Neoklis Georgopoulos, Evanthia Kassi, Georgios Mastorakos, Kali Makedou and 3 more

Abstract read
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In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Spyridon N KarrasLaboratory of Biological Chemistry, Medical School, Aristotle University, Thessaloniki, Greece.
Maria KypraiouAssisting Nature Centre of Reproduction and Genetics, Thessaloniki, Greece.
Vikentia HarizopoulouDepartment of Midwifery, Faculty of Health and Caring Sciences, University of West Attica, Athens, Greece.
Antonios VlastosLaboratory of Biological Chemistry, Medical School, Aristotle University, Thessaloniki, Greece.
Marios AnemoulisLaboratory of Biological Chemistry, Medical School, Aristotle University, Thessaloniki, Greece.
Maria DalamagaDepartment of Biological Chemistry, National and Kapodistrian University of Athens, Athens, Greece.
Neoklis GeorgopoulosDivision of Endocrinology, Department of Internal Medicine, School of Health Sciences, University of Patras, Patras, Greece.
Evanthia KassiDepartment of Biological Chemistry, National and Kapodistrian University of Athens, Athens, Greece.
Georgios MastorakosSecond Department of Surgery, Medical School, Aretaieio Athens Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Kali MakedouLaboratory of Biochemistry, American Hellenic Educational Progressive Association Hospital (AHEPA) University Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Dimitrios SkoutasThermi Clinic, Thessaloniki, Greece.
Melpomeni PeppaEndocrine Unit, 2ndPropaedeutic Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Dimitrios G GoulisUnit of Reproductive Endocrinology, 1stDepartment of Obstetrics and Gynecology, Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Vitamin D is increasingly recognized as a key modulator of growth, metabolism, and body composition in early life. However, the long-term impact of maternal vitamin D status and its multiple circulating forms on childhood anthropometry remains poorly understood. The KLOTHO cohort provides a unique opportunity to investigate these associations using detailed multi-form vitamin D profiles. Methods: Within the prospective KLOTHO cohort, serum concentrations of eight vitamin D metabolites [25(OH)D Results: Among 98 children with available follow-up data, cord-blood vitamin D metabolite profiles showed several exploratory trends of association with anthropometric measures assessed at 10-11 years of age. Directionally consistent associations were observed primarily for D Conclusions: In this exploratory analysis, multidimensional profiling of vitamin D metabolites at birth identified preliminary trends linking D

Indexed as

Child DevelopmentVitamin DBirth CohortChildFemaleHumansInfant, NewbornKlotho ProteinsMalePregnancyProspective StudiesTandem Mass SpectrometryKlotho ProteinsKL protein, humanVitamin Dchildren growthKLOTHO birth cohortmetabolitesvitamin (25[OH]D)vitamin D

Identifiers

PMID41958885
PMCPMC13056814

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.