Evidence map›Paper›PMID 41958860›Full record

ArticlePain reports2026

White matter microstructure of sensorimotor projection fibers in chronic low back pain.

John R Gilliam, Jennifer M C Vendemia, Zachary Baty, Sheri P Silfies, Stephen A Coombes

Abstract read
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In one paragraph

Article in Pain reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

John R GilliamLaboratory for Rehabilitation Neuroscience, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA.
Jennifer M C VendemiaDepartment of Psychology, University of South Carolina, Columbia, SC, USA.
Zachary BatyLaboratory for Rehabilitation Neuroscience, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA.
Sheri P SilfiesSpine Neuromechanics Lab, Department of Physical Therapy, University of Delaware, Newark, DE, USA.
Stephen A CoombesLaboratory for Rehabilitation Neuroscience, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA.ORCID https://orcid.org/0000-0002-9998-6513

Funding

Linking Altered Cortical Sensorimotor Integration with Movement Impairments in Back PainR01HD095959 · NICHD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI SILFIES, SHERI P, VENDEMIA, JENNIFER MARY · 2018 to 2022
$1.6M
NICHD NIH HHS R01 HD095959
6 · The paper itself

Abstract

Introduction: Chronic low back pain (cLBP) is linked to altered cortical sensorimotor structure and function, yet white matter microstructure in sensorimotor projection fibers remains poorly characterized. Methods: We estimated an array of microstructural measures, including fractional anisotropy (FA), extracellular free water fraction (FW), free water-corrected FA (fwcFA), and neurite orientation dispersion and density imaging (NODDI) metrics. Results: General linear models identified significantly higher FA and fwcFA and lower orientation dispersion index (ODI) in cLBP vs HC within projection fibers emanating from the primary somatosensory and motor cortices (all corrected Conclusion: Our results align differences in white matter microstructure with previous neurophysiological evidence that identifies the primary sensorimotor cortices as relevant in cLBP and emphasizes the interrelatedness of anxiety and depressive symptoms and sensorimotor structure.

Indexed as

AnxietyChronic painDiffusion MRILow back painWhite matter

Identifiers

PMID41958860
PMCPMC13061524

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.