Evidence map›Paper›PMID 41958843›Full record

ArticleGigaByte (Hong Kong, China)2025

EMImR: a Shiny application for identifying transcriptomic and epigenomic changes.

Hiba Ben Aribi, Careen Naitore, Farah Ayadi, Souheila Guerbouj, Olaitan I Awe

Abstract read
In one paragraph

Article in GigaByte (Hong Kong, China), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hiba Ben AribiFaculty of Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia.ORCID https://orcid.org/0000-0001-9547-8725
Careen NaitoreJomo Kenyatta University of Agriculture and Technology, Kenya.ORCID https://orcid.org/0000-0003-3325-5176
Farah AyadiFaculty of Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia.ORCID https://orcid.org/0000-0002-1000-0376
Souheila GuerboujFaculty of Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia.ORCID https://orcid.org/0000-0002-3195-9789
Olaitan I AweDepartment of Computer Science, Faculty of Science, University of Ibadan, Ibadan, Oyo State, Nigeria.ORCID https://orcid.org/0000-0002-4257-3611

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Identifying differentially expressed genes associated with genetic pathologies is crucial to understanding the biological differences between healthy and diseased states and identifying potential biomarkers and therapeutic targets. However, gene expression profiles are controlled by various mechanisms, including epigenomic changes, such as DNA methylation, histone modifications, and interfering microRNA silencing. We developed a novel Shiny application for transcriptomic and epigenomic change identification and correlation using a combination of Bioconductor and CRAN packages. The developed package, named EMImR, is a user-friendly tool with an easy-to-use graphical user interface to identify differentially expressed genes, differentially methylated genes, and differentially expressed interfering microRNA. In addition, it identifies the correlation between transcriptomic and epigenomic modifications and performs the ontology analysis of genes of interest. The developed tool could be used to study the regulatory effects of epigenetic factors. The application is publicly available in the GitHub repository (https://github.com/omicscodeathon/emimr).

Identifiers

PMID41958843
PMCPMC13058446

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.