ArticleFrontiers in bioengineering and biotechnology2026
Hydroxypropyl methylcellulose stearoxy ether hydrogel loaded with
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Corrections and comments
- Erratum issued
Authors and funding
14 authors.
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Abstract
Background: The impaired healing of diabetic wounds under hyperglycemic conditions presents a major challenge. While Methods: AVp-EVMs were produced via high-pressure homogenization and ultracentrifugation. Their effects on keratinocyte (HaCaT) proliferation/migration and anti-inflammatory activity in LPS-stimulated macrophages were assessed Results: AVp-EVMs showed good biocompatibility, promoted keratinocyte proliferation and migration, and were effectively internalized. They suppressed LPS-induced inflammation in macrophages by inhibiting NF-κB activation and downstream pro-inflammatory cytokines (TNF-α, IL-1β, IL-6). The Sangelose hydrogel preserved the AVp-EVMs structure better than the Carbomer hydrogel. In diabetic mice, both AVp-EVMs and HG-EVM dressing promoted wound healing by enhancing re-epithelialization, reducing inflammation, and improving collagen deposition and alignment. The HG-EVM group achieved the highest wound closure rate (97.2%), significantly outperforming free AVp-EVMs injection (94.9%; Conclusion: This study establishes a production method for AVp-EVMs. The non-ionic Sangelose hydrogel is an effective delivery vehicle, and the HG-EVM formulation enhances diabetic wound healing more effectively than free AVp-EVMs alone.
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