ArticleChina CDC weekly2026
Longitudinal Trajectories of Growth and Development in HIV-Exposed Uninfected Children from a Long-Term Birth Cohort - 8 Regions, 3 PLADs, China, 2017-2024.
Article in China CDC weekly, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study examined growth and development trajectories in Human Immunodeficiency Virus (HIV) exposed children aged 0-3 years, identified key influencing factors, and generated evidence to support early developmental promotion in this population. Methods: This prospective cohort study enrolled pregnant women who delivered between January 2017 and June 2021 and followed their infants until 3 years of age. Participants were drawn from a mother-to-child HIV transmission cohort established across Guangxi Zhuang Autonomous Region, Yunnan Province, and Xinjiang Uygur Autonomous Region. Chi-square tests were used to compare differences between groups, and generalized estimating equations (GEE) were applied to identify factors influencing growth and nutritional outcomes in HIV-exposed children. Results: The cohort comprised 1,227 mother-child pairs: 411 in the exposed group (HIV-infected mothers) and 816 in the control group (non-HIV-infected mothers). The malnutrition rate among HIV-exposed children in the study regions was 12.00%. Relative to the control group, HIV-exposed children demonstrated significantly lower height and weight gains and a higher prevalence of malnutrition ( Conclusions: HIV-exposed children in the study regions demonstrated modestly poorer overall growth and development compared with non-exposed peers. These findings underscore the importance of targeted nutritional interventions, early developmental surveillance, and timely correction of growth abnormalities in this vulnerable population.
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