Evidence map›Paper›PMID 41958732›Full record

ArticleEcology and evolution2026

Genome-Wide 6mA Map Unveils Epigenetic Adaptation in Deep-Sea Limpet.

Chengqin Chen, Jianhui Liu, Ruhao Zhuang, Kuo Ni, Minxiao Wang, Yuli Li, Jing Wang, Shi Wang, Wentao Han, Lisui Bao

Abstract read
In one paragraph

Article in Ecology and evolution, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chengqin ChenFang Zongxi Center for Marine Evo-Devo, MOE Key Laboratory of Marine Genetics and Breeding & Shandong Key Laboratory of Marine Seed Industry Ocean University of China Qingdao China.
Jianhui LiuFang Zongxi Center for Marine Evo-Devo, MOE Key Laboratory of Marine Genetics and Breeding & Shandong Key Laboratory of Marine Seed Industry Ocean University of China Qingdao China.
Ruhao ZhuangFang Zongxi Center for Marine Evo-Devo, MOE Key Laboratory of Marine Genetics and Breeding & Shandong Key Laboratory of Marine Seed Industry Ocean University of China Qingdao China.
Kuo NiFang Zongxi Center for Marine Evo-Devo, MOE Key Laboratory of Marine Genetics and Breeding & Shandong Key Laboratory of Marine Seed Industry Ocean University of China Qingdao China.
Minxiao WangKey Laboratory of Marine Ecology and Environmental Sciences and Deep Sea Research Center, Institute of Oceanology Chinese Academy of Sciences Qingdao China.
Yuli LiFang Zongxi Center for Marine Evo-Devo, MOE Key Laboratory of Marine Genetics and Breeding & Shandong Key Laboratory of Marine Seed Industry Ocean University of China Qingdao China.
Jing WangFang Zongxi Center for Marine Evo-Devo, MOE Key Laboratory of Marine Genetics and Breeding & Shandong Key Laboratory of Marine Seed Industry Ocean University of China Qingdao China.
Shi WangFang Zongxi Center for Marine Evo-Devo, MOE Key Laboratory of Marine Genetics and Breeding & Shandong Key Laboratory of Marine Seed Industry Ocean University of China Qingdao China.
Wentao HanFang Zongxi Center for Marine Evo-Devo, MOE Key Laboratory of Marine Genetics and Breeding & Shandong Key Laboratory of Marine Seed Industry Ocean University of China Qingdao China.
Lisui BaoFang Zongxi Center for Marine Evo-Devo, MOE Key Laboratory of Marine Genetics and Breeding & Shandong Key Laboratory of Marine Seed Industry Ocean University of China Qingdao China.ORCID https://orcid.org/0000-0001-8196-3375

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

How animals thrive in extreme deep-sea environments remains a key question in marine evolutionary biology. While adaptation is often studied through the lens of genetic sequence, the epigenetic mechanisms that allow for phenotypic plasticity and rapid environmental response in these organisms remain a major "black box". DNA N6-methyladenine (6mA) is an emerging epigenetic mark in eukaryotes, but its presence and role in deep-sea animals remain unknown. Here, we present the first genome-wide map of DNA 6mA in a deep-sea animal, the cold seep limpet

Indexed as

Bathyacmaea lacteadeep‐sea cold seepsDNA N6‐methyladenine (6mA)epigenetic adaptationsPacBio SMRT sequencing

Identifiers

PMID41958732
PMCPMC13058721

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.