Evidence map›Paper›PMID 41958710›Full record

ArticleOphthalmology science2026

Association of Seasonal Hyperacute Panuveitis Syndrome with

Kenji Nakamichi, Anu Manandhar, Smita Shrestha, Miel Sundararajan, Manish P Poudel, Biraj Man Karmacharya, Astaram Bade, Pradeep Banjara, Angira Shrestha, Angela Sandt and 4 more

Abstract read
In one paragraph

Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kenji NakamichiDepartment of Ophthalmology, University of Washington School of Medicine, Seattle, Washington.
Anu ManandharUveitis Division, Tilganga Institute of Ophthalmology, Kathmandu, Nepal.
Smita ShresthaUveitis Division, Tilganga Institute of Ophthalmology, Kathmandu, Nepal.
Miel SundararajanDepartment of Ophthalmology, University of Washington School of Medicine, Seattle, Washington.
Manish P PoudelUveitis Division, Tilganga Institute of Ophthalmology, Kathmandu, Nepal.
Biraj Man KarmacharyaUveitis Division, Tilganga Institute of Ophthalmology, Kathmandu, Nepal.
Astaram BadeUveitis Division, Tilganga Institute of Ophthalmology, Kathmandu, Nepal.
Pradeep BanjaraUveitis Division, Tilganga Institute of Ophthalmology, Kathmandu, Nepal.
Angira ShresthaDepartment of Ophthalmology, Dulikhel Hospital, Dulikhel, Nepal.
Angela SandtDepartment of Ophthalmology, University of Washington School of Medicine, Seattle, Washington.
Gabrielle TurskiDepartment of Ophthalmology, University of Washington School of Medicine, Seattle, Washington.
Ethan D BuhrDepartment of Ophthalmology, University of Washington School of Medicine, Seattle, Washington.
Apoorva ChowdharyDepartment of Ophthalmology, University of Washington School of Medicine, Seattle, Washington.
Russell N Van GelderDepartment of Ophthalmology, University of Washington School of Medicine, Seattle, Washington.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To identify potential infectious agents in cases of seasonal hyperacute panuveitis syndrome (SHAPU) from vitreous biopsies of patients with this disorder. Design: A retrospective cohort analysis. Subjects: Vitreous biopsies were obtained during the course of care from 53 subjects with SHAPU. Methods: DNA extraction and whole genome shotgun sequencing was performed using Oxford Nanopore long read sequencing. Sequences were matched against microbial and human databases. Visual outcomes at presentation and at 6 months were recorded. Main Outcome Measures: Identification and characterization of metagenomic sequences in vitreous isolates from subjects with SHAPU. Results: Adequate DNA for sequencing was obtained from 32 SHAPU subjects. Fifteen samples yielded bacteria on culture, with 14 Conclusions: The majority of SHAPU cases show molecular evidence for concurrent Financial Disclosures: The authors have no proprietary or commercial interest in any materials discussed in this article.

Indexed as

EndophthalmitisMetagenomic sequencingSeasonal hyperacute Panuveitis SyndromeSHAPUStreptococcus pneumoniae

Identifiers

PMID41958710
PMCPMC13059302

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.