ArticleJournal of human reproductive sciences
Comparison of the Effect of Ketofol and Ketodex as Procedural Sedation and Analgesia for Oocyte Retrieval during
Article in Journal of human reproductive sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Oocyte retrieval requires effective sedation that ensures patient comfort without compromising reproductive outcomes. Although multiple sedative agents are routinely employed during oocyte retrieval, the optimal sedative regimen remains an active research area. Aim: The aim of this study was to compare the analgesic efficacy and safety of Ketodex (ketamine-dexmedetomidine) versus Ketofol (ketamine-propofol) for procedural sedation for oocyte retrieval during Settings and Design: Double blinded, single-centre, randomised controlled pilot study at a tertiary-care IVF centre. Materials and Methods: Sixty American Society of Anesthesiologists I-II women (20-40 years) scheduled for transvaginal oocyte retrieval were randomised to receive Ketofol (ketamine + propofol) or Ketodex (ketamine + dexmedetomidine) ( Statistical Analysis Used: Two-group comparison was done with the Mann-Whitney Results: VAS scores decreased over time in both groups, but were significantly lower in the Ketodex group at all post-operative time points (10 min; 30 min; 1 h; 2 h, Conclusion: Ketodex demonstrated superior analgesic efficacy, opioid sparing and improved safety compared to Ketofol.
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